Evidence map›Paper›PMID 39413990›Full record

ArticleContemporary clinical trials2024

Neural and metabolic factors in carbohydrate reward: Rationale, design, and methods for a flavor-nutrient learning paradigm in humans.

Amber L Kelly, Mary Elizabeth Baugh, Monica L Ahrens, Abigail N Valle, Rhianna M Sullivan, Mary E Oster, Mary E Fowler, Bridget E Carter, Brenda M Davy, Alexandra L Hanlon and 1 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06053294 (Neural and Metabolic Factors in Carbohydrate Reward), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06053294 narecruitingnot on this map

Neural and Metabolic Factors in Carbohydrate Reward: An Examination of Speed

TypeinterventionalSponsorVirginia Polytechnic Institute and State UniversityRan2023 to 2029Enrolled64ConditionsCarbohydrate MetabolismArmsCS- Beverage, CS+Fast, CS+Slow
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Amber L KellyFralin Biomedical Research Institute at VTC, Roanoke, VA, USA; Center for Health Behaviors Research at Fralin Biomedical Research Institute at VTC, Roanoke, VA, USA; Translational Biology, Medicine, and Health, Fralin Biomedical Research Institute at VTC, Roanoke, VA, USA.
Mary Elizabeth BaughFralin Biomedical Research Institute at VTC, Roanoke, VA, USA; Center for Health Behaviors Research at Fralin Biomedical Research Institute at VTC, Roanoke, VA, USA.
Monica L AhrensCenter for Biostatistics and Health Data Science, Department of Statistics, Blacksburg, VA, USA.
Abigail N ValleDepartment of Biological Sciences, Virginia Tech, Blacksburg, VA, USA.
Rhianna M SullivanSchool of Neuroscience, Virginia Tech, Blacksburg, VA, USA.
Mary E OsterFralin Biomedical Research Institute at VTC, Roanoke, VA, USA; Center for Health Behaviors Research at Fralin Biomedical Research Institute at VTC, Roanoke, VA, USA.
Mary E FowlerFralin Biomedical Research Institute at VTC, Roanoke, VA, USA; Center for Health Behaviors Research at Fralin Biomedical Research Institute at VTC, Roanoke, VA, USA.
Bridget E CarterFralin Biomedical Research Institute at VTC, Roanoke, VA, USA; Center for Health Behaviors Research at Fralin Biomedical Research Institute at VTC, Roanoke, VA, USA.
Brenda M DavyDepartment of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, VA, USA.
Alexandra L HanlonCenter for Biostatistics and Health Data Science, Department of Statistics, Blacksburg, VA, USA.
Alexandra G DiFeliceantonioFralin Biomedical Research Institute at VTC, Roanoke, VA, USA; Center for Health Behaviors Research at Fralin Biomedical Research Institute at VTC, Roanoke, VA, USA; Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, VA, USA. Electronic address: dife@vt.edu.

Funding

Ultra-processed food reward: neural and metabolic factorsR01DK132389 · NIDDK · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Alexandra Gold DiFeliceantonio · 2023 to 2026
$1.8M
NIDDK NIH HHS R01 DK132389
6 · The paper itself

Abstract

Overconsumption of ultra-processed foods (UPFs), which are linked with adverse health outcomes, is a growing public health concern. UPFs deliver highly bioavailable calories rapidly, which may contribute to their reinforcing potential and drive overconsumption. Our primary aim is to test the role of speed of nutrient availability on reward learning. We hypothesize that brain activity in reward related areas and behavioral preferences will be greater to a flavored drink predicting rapidly available calories (CS + Fast) compared with a flavored drink predicting more slowly available (CS + Slow) or no (CS-) calories. Participants (n = 64, aged 18-45 years, will consume 3 novel flavored, isosweet beverages containing 110 kcal of sucrose (CS + Fast), 110 kcal of maltodextrin (CS + Slow), or 0-kcal sucralose (CS-) 6 times in randomized, crossover order. Blood metabolites and indirect calorimetry measures, including metabolic rate and carbohydrate oxidation, will be assessed before and for 1 h after beverage consumption. Behavioral preference for beverages will be assessed in a pre- and post-test. Brain response to each flavor without calories will be assessed via functional magnetic resonance imaging in a post-test. Findings from this study will contribute to the understanding of basic mechanisms that may drive overconsumption of UPFs. Trial registration:clinicaltrials.gov registration #NCT06053294.

Indexed as

BrainDietary CarbohydratesRewardAdolescentAdultCross-Over StudiesEnergy IntakeFemaleFlavoring AgentsFood PreferencesHumansLearningMagnetic Resonance ImagingMaleMiddle AgedPolysaccharidesDietary CarbohydratesFlavoring AgentsmaltodextrinPolysaccharidesSucrosetrichlorosucroseCarbohydrateFunctional magnetic resonance imagingReinforcementReward learning

Identifiers

PMID39413990
PMCPMC11688656

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.