ArticleCell stem cell2024
A distinct metabolic and epigenetic state drives trained immunity in HSC-derived macrophages from autoimmune mice.
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Article in Cell stem cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31citing papers in PubMed
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Who cites it
31 citing papers in PubMed.
- Review
- The theory of the inflammatory ecosystem.Science China. Life sciences · 2026Review
- Trained immunity: An unexplored component of IBD pathogenesis.Inflammatory bowel diseases · 2026Review
- Migration of immune cells in tumors and inflammation: molecular mechanisms and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Emergency granulopoiesis and innate immune memory in inflammatory bowel disease.Trends in immunology · 2026Review
- Review
- HIV-1 Nef generates lasting innate immune memory in haematopoietic stem and progenitor cells in vivo.EMBO reports · 2026Article
- Ocular IL-1α/IFN-γ Delay the Corneal Wound Healing in Rheumatoid Arthritis Through Mitochondrial Dysfunction and NLRP3 Inflammasome Activation.Investigative ophthalmology & visual science · 2026Article
- Targeting the cytokine-epigenetic axis: a new paradigm and prospects for disease treatment.European cytokine network · 2026Review
- Trained immunity modulators: A new frontier in immunoregulation and disease intervention.Journal of advanced research · 2026Review
- Review
- Monocyte/macrophage-mediated trained immunity in disease prevention and immunotherapy.Bioactive materials · 2026Review
- Tissue context as a determinant of trained innate immunity: a conserved molecular toolkit with divergent functional outputs.Journal of leukocyte biology · 2026Review
- Rare epigenetic alterations are conserved across hematopoietic differentiation stages after mycobacterial infection.JCI insight · 2026Article
- Immune signaling as a determinant of cellular identity and tissue function.Frontiers in immunology · 2026Review
- Circadian clock-gut microbiota axis in pulmonary hypertension: linking gut-lung crosstalk, immune timing and vascular remodeling.Frontiers in physiology · 2026Review
- Trained immunity in lung injury and repair.Frontiers in immunology · 2026Review
- Trained immunity: induction of an inflammatory memory in disease.Cell research · 2025Review
- Ageing, immune fitness and cancer.Nature reviews. Cancer · 2025Review
- Trained Immunity in Health and Disease.MedComm · 2025Review
Corrections and comments
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Authors and funding
19 authors.
Taylor S MillsDivision of Hematology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Immunology Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Bailee KainGraduate Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, Houston, TX 77030, USA.
Matt A BurchillDivision of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Etienne DanisDepartment of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; University of Colorado Comprehensive Cancer Center, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Erin D LucasImmunology Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Division of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Rachel Culp-HillDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Courtney M CowanDivision of Hematology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Immunology Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Wolfgang E SchleicherDivision of Hematology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Sweta B PatelDivision of Hematology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Brandon T TranGraduate Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, Houston, TX 77030, USA.
Ruoqiong CaoGraduate Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, Houston, TX 77030, USA.
Andrew GoodspeedDepartment of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; University of Colorado Comprehensive Cancer Center, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Sarah FerraraUniversity of Colorado Comprehensive Cancer Center, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Shaun BeversDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Beth A Jirón TamburiniImmunology Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Division of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
James R RoedeDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO 80045, USA.
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Katherine Y KingDepartment of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, Houston, TX 77030, USA.
Eric M PietrasDivision of Hematology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: eric.pietras@cuanschutz.edu.
Funding
University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0MHematology Training ProgramT32DK060445 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI GOODELL, MARGARET A. · 2002 to 2023
$8.3MTraining In Cell and Gene TherapyT32HL092332 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI MALCOLM K. BRENNER, Bruno Di Stefano · 2008 to 2026
$6.9MResearch Training in Rheumatology INCLUDE Down Syndrome SupplementT32AR007534 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI Kristine A. Kuhn · 1986 to 2026
$6.1MThe role of ferroptosis in red cell aging in vivo and in vitroR01HL146442 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Angelo D'Alessandro, Adam N. Goldfarb · 2019 to 2026
$5.4MImpact of Infection and Inflammation on Primitive HematopoiesisR35HL155672 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Katherine Yudeh King · 2021 to 2026
$5.1MCooperation between lymphatic stroma and hematopoietic cells shapes protective immunityR01AI121209 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Beth Ann Tamburini · 2016 to 2026
$4.5MImpact of IL-1 signaling on hematopoietic stem cell function and emergence of clonal hematopoiesis.R01DK119394 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI PIETRAS, ERIC M · 2019 to 2023
$2.0MOxidized LDL dependent reprogramming of the liver lymphatic endotheliumR01DK125595 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI BURCHILL, MATTHEW A · 2020 to 2023
$1.7MPro-inflammatory cytokines in hematopoietic stem cell functionK01DK098315 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI PIETRAS, ERIC M · 2014 to 2018
$691kEpigenetic modification of hematopoietic stem and progenitor cells in inflammation-induced differentiationF31HL164287 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI TRAN, BRANDON T · 2022 to 2024
$143kNCI NIH HHS P30 CA046934NHLBI NIH HHS F31 HL164287NHLBI NIH HHS R01 HL146442NHLBI NIH HHS R35 HL155672NHLBI NIH HHS T32 HL092332NIAID NIH HHS R01 AI121209NIAMS NIH HHS T32 AR007534NIDDK NIH HHS K01 DK098315NIDDK NIH HHS R01 DK119394NIDDK NIH HHS R01 DK125595NIDDK NIH HHS T32 DK060445
Abstract
Here, we investigate the contribution of long-term hematopoietic stem cells (HSCs
Indexed as
Epigenesis, GeneticHematopoietic Stem CellsMacrophagesAnimalsAutoimmunityDisease Models, AnimalGlycolysisLupus Erythematosus, SystemicMiceMice, Inbred C57BLTrained Immunityautoimmune diseasebone marrow-derived macrophagehematopoietic stem cellinflammationmetabolismtrained immunity
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.