Evidence map›Paper›PMID 39413769›Full record

ArticleBritish journal of haematology2024

CDK8/19 inhibition triggers a switch from mitosis to endomitosis in cord blood megakaryocytes.

Zhi-Jian Liu, Christopher Thom, Ioana I Nitulescu, Henry E Pelish, Lisa M Rimsza, Raul Teruel-Montoya, Francisca Ferrer-Marin, Matthew D Shair, Martha Sola-Visner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of haematology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Inflammation, anemia, and vitamin D levels associate with infant thrombocytosis risk.Research and practice in thrombosis and haemostasis · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhi-Jian LiuDivision of Newborn Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Christopher ThomDivision of Neonatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-1830-9922
Ioana I NitulescuDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.
Henry E PelishDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.
Lisa M RimszaDepartment of Pathology, University of Arizona, Tucson, Arizona, USA.ORCID https://orcid.org/0000-0003-1268-2750
Raul Teruel-MontoyaHematology Department, Hospital Universitario Morales-Meseguer, Centro Regional de Hemodonación, CIBERER (U765), IMIB, Universidad Católica San Antonio (UCAM), Murcia, Spain.
Francisca Ferrer-MarinHematology Department, Hospital Universitario Morales-Meseguer, Centro Regional de Hemodonación, CIBERER (U765), IMIB, Universidad Católica San Antonio (UCAM), Murcia, Spain.
Matthew D ShairDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.
Martha Sola-VisnerDivision of Newborn Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Funding

THE RoLE OF NEONATAL ANEMIA IN LEARNING AND MEMORYP01HL046925 · NHLBI · UNIVERSITY OF IOWA · PI SOLA-VISNER, MARTHA C. · 1992 to 2022
$34.3M
Prolonged and Severe Thrombocytopenia in NeonatesR01HL069990 · NHLBI · UNIVERSITY OF FLORIDA · PI SOLA-VISNER, MARTHA C. · 2002 to 2015
$2.8M
Determining genetic mechanisms that drive in vitro hematopoiesisK99HL156052 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI THOM, CHRISTOPHER STEPHEN · 2021 to 2024
$670k
NHLBI NIH HHS HL046925NHLBI NIH HHS HL156052NHLBI NIH HHS HL69990NHLBI NIH HHS K99 HL156052NHLBI NIH HHS P01 HL046925NHLBI NIH HHS R01 HL069990
6 · The paper itself

Abstract

Neonatal and adult megakaryocytes differ in proliferative capacity and ploidy levels, and neonatal and adult platelets differ in function, gene expression, and protein content. The mechanisms underlying these differences are incompletely understood. CDK8 and CDK19 are transcriptional kinases part of the CDK-mediator complex, which regulates gene transcription in a cell-specific manner. We discovered that cortistatin A, a potent highly selective inhibitor of CDK8/CDK19, significantly reduced cell expansion and increased ploidy in cord blood-derived megakaryocytes. These phenotypic changes were associated with gene expression changes that partially overlapped developmentally regulated genes. These findings might have relevance for the management of developmental megakaryocyte disorders.

Indexed as

Cyclin-Dependent Kinase 8Cyclin-Dependent KinasesFetal BloodMegakaryocytesMitosisCell ProliferationCells, CulturedHumansPloidiesProtein Kinase InhibitorsCDK19 protein, humanCDK8 protein, humanCyclin-Dependent Kinase 8Cyclin-Dependent KinasesProtein Kinase Inhibitorscord bloodmegakaryocytesneonatal haematologytranscription

Identifiers

PMID39413769
PMCPMC11637730

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.