Evidence map›Paper›PMID 39413367›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Molecular Engineering of a Tumor-Targeting Thione-Derived Diketopyrrolopyrrole Photosensitizer to Attain NIR Excitation Over 850 nm for Efficient Dual Phototherapy.

Gang Xu, Yunxia Song, Haifeng Jin, Pengmin Shi, Yubo Jiao, Fangzhou Cao, Jie Pang, Yanyan Sun, Lei Fang, Xing-Hua Xia and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gang XuJiangsu Province Hi-Tech Key Laboratory for Biomedical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China.ORCID 0000-0003-4974-9496
Yunxia SongJiangsu Province Hi-Tech Key Laboratory for Biomedical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China.
Haifeng JinJiangsu Province Hi-Tech Key Laboratory for Biomedical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China.
Pengmin ShiJiangsu Province Hi-Tech Key Laboratory for Biomedical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China.
Yubo JiaoJiangsu Province Hi-Tech Key Laboratory for Biomedical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China.
Fangzhou CaoJiangsu Province Hi-Tech Key Laboratory for Biomedical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China.
Jie PangState Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China.
Yanyan SunSchool of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou, 215009, China.ORCID 0000-0002-4398-4703
Lei FangJiangsu Province Hi-Tech Key Laboratory for Biomedical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China.
Xing-Hua XiaState Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China.ORCID 0000-0001-9831-4048
Jian ZhaoJiangsu Province Hi-Tech Key Laboratory for Biomedical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China.ORCID 0000-0002-9365-7727

Funding

Fundamental Research Funds for Central Universities of the Central South University 2242024K40034Innovative Research Group Project of the National Natural Science Foundation of China 22271045Jiangsu Province Hi-tech Key Laboratory for Biomedical ResearchState Key Laboratory of Analytical Chemistry for Life Sciences SKLACLS2414
6 · The paper itself

Abstract

Photosensitizers with near-infrared (NIR) excitation, especially above 800 nm which is highly desired for phototherapy, remain rare due to the fast nonradiative relaxation process induced by exciton-vibration coupling. Here, a diketopyrrolopyrrole-derived photosensitizer (DTPA-S) is developed via thionation of carbonyl groups within the diketopyrrolopyrrole skeleton, which results in a large bathochromic shift of 81 nm, endowing the photosensitizer with strong NIR absorption at 712 nm. DTPA-S is then introduced with a functional biomolecule (N

Indexed as

Photosensitizing AgentsAnimalsCell Line, TumorDisease Models, AnimalHumansInfrared RaysKetonesMiceNanoparticlesPhotochemotherapyPhototherapyPyrrolesThionesdiketopyrrolopyrrole dyeKetonesPhotosensitizing AgentsPyrrolesThionesdiketopyrrolopyrroleNIR excitationsphotodynamic therapyphotothermal therapythiocarbonyl‐substitutes

Identifiers

PMID39413367
PMCPMC11615798

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.