Evidence map›Paper›PMID 39413185›Full record

ArticleScience advances2024

Directly monitoring the dynamic in vivo metabolisms of hyperpolarized

Yohei Kondo, Yutaro Saito, Tomohiro Seki, Yoichi Takakusagi, Norikazu Koyasu, Keita Saito, Jumpei Morimoto, Hiroshi Nonaka, Koichiro Miyanishi, Wataru Mizukami and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Hyperpolarized γ-Glutamyl-[1-Molecular imaging and biology · 2026
    Article
  2. Review
  3. Article
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yohei KondoDepartment of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.ORCID 0000-0003-2750-6661
Yutaro SaitoDepartment of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.ORCID 0000-0001-7610-121X
Tomohiro SekiCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Yoichi TakakusagiQuantum Hyperpolarized MRI Research Team, Quantum Life Spin Group, Institute for Quantum Life Science (iQLS), National Institutes for Quantum Science and Technology (QST), Anagawa 4-9-1, Inage, Chiba-city 263-8555, Japan.ORCID 0000-0002-6786-0748
Norikazu KoyasuCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Keita SaitoQuantum Hyperpolarized MRI Research Team, Quantum Life Spin Group, Institute for Quantum Life Science (iQLS), National Institutes for Quantum Science and Technology (QST), Anagawa 4-9-1, Inage, Chiba-city 263-8555, Japan.
Jumpei MorimotoDepartment of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.ORCID 0000-0002-8393-9616
Hiroshi NonakaDepartment of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.ORCID 0000-0003-4623-2926
Koichiro MiyanishiGraduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan.
Wataru MizukamiCenter for Quantum Information and Quantum Biology, Osaka University, Osaka 560-8531, Japan.ORCID 0000-0003-3538-3542
Makoto NegoroQuantum Hyperpolarized MRI Research Team, Quantum Life Spin Group, Institute for Quantum Life Science (iQLS), National Institutes for Quantum Science and Technology (QST), Anagawa 4-9-1, Inage, Chiba-city 263-8555, Japan.ORCID 0000-0003-3482-3198
Abdelazim E ElhelalyDepartment of Radiology, Frontier Science for Imaging, School of Medicine, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan.ORCID 0000-0001-6191-3194
Fuminori HyodoDepartment of Pharmacology, School of Medicine, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan.
Masayuki MatsuoDepartment of Radiology, School of Medicine, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan.
Natarajan RajuChemistry and Synthesis Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Rockville, MD 20850, USA.ORCID 0009-0002-5059-2246
Rolf E SwensonChemistry and Synthesis Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Rockville, MD 20850, USA.ORCID 0000-0001-7804-7202
Murali C KrishnaCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-7216-7788
Kazutoshi YamamotoCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-9405-5421
Shinsuke SandoDepartment of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.ORCID 0000-0003-0275-7237

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peptides play essential roles in biological phenomena, and, thus, there is a growing interest in detecting in vivo dynamics of peptide metabolisms. Dissolution-dynamic nuclear polarization (d-DNP) is a state-of-the-art technology that can markedly enhance the sensitivity of nuclear magnetic resonance (NMR), providing metabolic and physiological information in vivo. However, the hyperpolarized state exponentially decays back to the thermal equilibrium, depending on the spin-lattice relaxation time (

Indexed as

Carbon IsotopesOligopeptidesAnimalsKidneyMagnetic Resonance SpectroscopyMiceCarbon-13Carbon IsotopesOligopeptides

Identifiers

PMID39413185
PMCPMC11482307

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.