Evidence map›Paper›PMID 39413025›Full record

ArticleACS synthetic biology2024

Engineering Cyborg Pathogens through Intracellular Hydrogelation.

Shahid Khan, Pin-Ru Lin, Cheemeng Tan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS synthetic biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shahid KhanDepartment of Biomedical Engineering, University of California, Davis, Davis, California 95616, United States.
Pin-Ru LinDepartment of Biomedical Engineering, University of California, Davis, Davis, California 95616, United States.
Cheemeng TanDepartment of Biomedical Engineering, University of California, Davis, Davis, California 95616, United States.ORCID 0000-0003-1049-1192

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI KC KENT LLOYD · 2002 to 2026
$84.9M
Engineering and dissecting the synthetic non-dividing-but-active state of hybrid cell-materialsR35GM142788 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Cheemeng Tan · 2021 to 2026
$2.7M
Engineering non-proliferating-but-active (NPBA) probiotic for breast-cancer gene therapyR21CA267427 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HOVEY, RUSSELL C, TAN, CHEEMENG · 2022 to 2023
$374k
NCI NIH HHS P30 CA093373NCI NIH HHS R21 CA267427NIGMS NIH HHS R35 GM142788
6 · The paper itself

Abstract

Synthetic biology primarily focuses on two kinds of cell chassis: living cells and nonliving systems. Living cells are autoreplicating systems that have active metabolism. Nonliving systems, including artificial cells and nanoparticles, are nonreplicating systems typically lacking active metabolism. In recent work, Cyborg bacteria that are nonreplicating-but-metabolically active have been engineered through intracellular hydrogelation. Intracellular hydrogelation is conducted by infusing gel monomers and photoactivators into cells, followed by the activation of polymerization of the gel monomers inside the cells. However, the previous work investigated only

Indexed as

HydrogelsKlebsiella pneumoniaePseudomonas aeruginosaStaphylococcus aureusAnimalsMacrophagesMiceSynthetic BiologyHydrogelscyborg pathogenintracellular hydrogelationmacrophagesPseudomonas aeruginosaStaphylococcus aureussynthetic biology

Identifiers

PMID39413025
PMCPMC11748816

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.