Evidence map›Paper›PMID 39412740›Full record

ArticleJournal of nephrology2025

Potential benefits of hormone replacement therapy on cardiovascular and kidney outcomes in postmenopausal women with chronic kidney disease.

Semin Cho, Minsang Kim, Sehyun Jung, Jeong Min Cho, Seong Geun Kim, Sehoon Park, Soojin Lee, Eunjeong Kang, Yaerim Kim, Kwon Wook Joo and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Semin ChoDepartment of Internal Medicine, Chung-Ang University Gwangmyeong Hospital, Gyeonggi, Korea.
Minsang KimDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Sehyun JungDepartment of Internal Medicine, Gyeongsang National University Hospital, Jinju, Korea.
Jeong Min ChoDepartment of Internal Medicine, Chung-Ang University Gwangmyeong Hospital, Gyeonggi, Korea.
Seong Geun KimDepartment of Internal Medicine, Inje University Sanggye Paik Hospital, Seoul, Korea.
Sehoon ParkDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Soojin LeeDepartment of Internal Medicine, Uijeongbu Eulji University Medical Center, Gyeonggi, Korea.
Eunjeong KangTransplantation Center, Seoul National University Hospital, Seoul, Korea.
Yaerim KimDepartment of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
Kwon Wook JooDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Kyungdo HanDepartment of Statistics and Actuarial Science, Soongsil University, 369 Sangdo-ro, Dongjak-gu, Seoul, 06978, Republic of Korea. hkd917@naver.com.
Dong Ki KimDepartment of Translational Medicine, Seoul National University College of Medicine, Seoul, Korea.
Hyuk HuhDepartment of Translational Medicine, Seoul National University College of Medicine, Seoul, Korea. 109396@paik.ac.kr.

Funding

Busan Paik Hospital, Inje University 2023 research grantsCollege of Medicine, Seoul National University 800-20190571
6 · The paper itself

Abstract

backgroundHormone replacement therapy (HRT) is recommended for alleviating vasomotor symptoms or preventing bone loss in postmenopausal women. This study aimed to investigate the impact of hormone replacement therapy on major adverse cardiovascular events, kidney failure, and mortality in women with chronic kidney disease (CKD).

methodsThis population-based cohort study analyzed data from the National Cancer Screening Program and the national health examination of South Korea. Data on postmenopausal women were extracted from the 2009 National Cancer Screening Program. Among these postmenopausal women, those with CKD without kidney replacement therapy were selected through a national health examination from 2009 to 2013. The study outcomes were the risks of major adverse cardiovascular events, kidney failure, and all-cause mortality according to hormone replacement therapy.

resultsA total of 768,279 postmenopausal women with CKD were enrolled in this study; of these women, 13.8% (N = 106,052) had a history of hormone replacement therapy. The user and non-user groups differed with respect to baseline characteristics, with the latter being older and having risk factors for cardiovascular disease. After adjustment for confounding factors, the group exposed to hormone replacement therapy showed lower risks of major adverse cardiovascular events, kidney failure, and all-cause mortality.

conclusionsThis study suggests the potential benefits of hormone replacement therapy in postmenopausal women with CKD and highlighted its potential advantages for cardiovascular and kidney outcomes.

Indexed as

Cardiovascular DiseasesEstrogen Replacement TherapyHormone Replacement TherapyPostmenopauseRenal Insufficiency, ChronicAgedFemaleHumansMiddle AgedRepublic of KoreaRisk AssessmentRisk FactorsTreatment OutcomeCardiovascular diseaseChronic kidney diseaseHormone replacement therapyMenopause

Identifiers

PMID39412740

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.