Evidence map›Paper›PMID 39412642›Full record

ArticleJournal of cardiovascular translational research2025

Apolipoprotein A-I Mimetic Peptide Restores VEGF-induced Angiogenesis in Hypercholesterolemic Ischemic Heart by Reducing HDL Proinflammatory Properties.

Zui Liu, Yang Cao, Xiao-Long Liao, Zhi-Jun Ou, Zhi-Wei Mo, Yi-Fang Liu, Ya-Ting Chen, Ze-Long Liu, Jian-Jun Gao, Da-Sheng Ning and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zui Liu *Division of Cardiac Surgery, Cardiovascular Diseases Institute, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhong Shan Er Road, Guangzhou, 510080, China.
Yang Cao *Division of Cardiac Surgery, Cardiovascular Diseases Institute, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhong Shan Er Road, Guangzhou, 510080, China.
Xiao-Long Liao *Division of Cardiac Surgery, Cardiovascular Diseases Institute, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhong Shan Er Road, Guangzhou, 510080, China.
Zhi-Jun Ou *National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, NHC Key Laboratory of Assisted Circulation and Vascular Diseases (Sun Yat-Sen University), Key Laboratory of Assisted Circulation and Vascular Diseases, Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases, Chinese Academy of Medical Sciences, Guangzhou, 510080, China.
Zhi-Wei Mo *Division of Cardiac Surgery, Cardiovascular Diseases Institute, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhong Shan Er Road, Guangzhou, 510080, China.
Yi-Fang LiuDivision of Cardiac Surgery, Cardiovascular Diseases Institute, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhong Shan Er Road, Guangzhou, 510080, China.
Ya-Ting ChenDivision of Cardiac Surgery, Cardiovascular Diseases Institute, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhong Shan Er Road, Guangzhou, 510080, China.
Ze-Long LiuDivision of Cardiac Surgery, Cardiovascular Diseases Institute, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhong Shan Er Road, Guangzhou, 510080, China.
Jian-Jun GaoDivision of Cardiac Surgery, Cardiovascular Diseases Institute, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhong Shan Er Road, Guangzhou, 510080, China.
Da-Sheng NingDivision of Cardiac Surgery, Cardiovascular Diseases Institute, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhong Shan Er Road, Guangzhou, 510080, China.
Yue-Ming PengDivision of Cardiac Surgery, Cardiovascular Diseases Institute, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhong Shan Er Road, Guangzhou, 510080, China.
Mary G Sorci-ThomasCardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI, 53226, USA. msthomas@mcw.edu.
Jing-Song OuDivision of Cardiac Surgery, Cardiovascular Diseases Institute, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhong Shan Er Road, Guangzhou, 510080, China. oujs@mail.sysu.edu.cn.ORCID 0000-0001-5517-3142
Yan LiDivision of Cardiac Surgery, Cardiovascular Diseases Institute, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhong Shan Er Road, Guangzhou, 510080, China. li_yan_lee@126.com.

Funding

Pcpe2 in Adipose Tissue Expansion and Lipoprotein MetabolismR01DK139164 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI Mary G Sorci-Thomas · 2024 to 2026
$2.0M
Role of Pcpe2 in Adipose Tissue Remodeling and Lipoprotein MetabolismR56DK134396 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI SORCI-THOMAS, MARY G · 2023 to 2023
$195k
Basic and Applied Basic Research Foundation of Guangdong Province 2024A1515030041National Key R&D Program of China 2021YFA0805100National Natural Science Foundation of China 81325001National Natural Science Foundation of China 81830013National Natural Science Foundation of China 82270485National Natural Science Foundation of China 92268202NIDDK NIH HHS R01 DK139164NIDDK NIH HHS R56 DK134396NIH HHS NIH RO1DK139164Science and Technology Planning Project of Guangdong Province 2023B1212060018the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences 2023-PT320-03
6 · The paper itself

Abstract

VEGF-induced angiogenesis is impaired in hypercholesterolemia. Previous studies showed that an apolipoprotein A-I(ApoA-I) mimetic peptide, D-4F, is able to reduce HDL proinflammatory index in hypercholesterolemia. Whether D-4F promotes angiogenesis in hypercholesterolemia remains unclear. Low-density lipoprotein receptor null (LDLr

Indexed as

Apolipoprotein A-IHypercholesterolemiaInflammation MediatorsLipoproteins, HDLMyocardial InfarctionMyocardiumNeovascularization, PhysiologicPeptidesVascular Endothelial Growth Factor AAngiogenesisAnimalsDisease Models, AnimalMaleMice, Inbred C57BLMice, KnockoutNitric Oxide Synthase Type IIIApolipoprotein A-Iapolipoprotein A-I mimetic peptide 4FD-4F peptideInflammation MediatorsLipoproteins, HDLNitric Oxide Synthase Type IIINos3 protein, mousePeptidesReceptors, LDLVascular Endothelial Growth Factor Avascular endothelial growth factor A, mouseAngiogenesisApolipoprotein A-IHigh-density lipoproteinProinflammatoryVascular endothelial growth factor

Identifiers

PMID39412642
PMCPMC11885385

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.