Evidence map›Paper›PMID 39412576›Full record

ArticleImmunologic research2024

Differential analysis of sorting nexin 10 and sterol regulatory element-binding protein 2 expression in inflammatory bowel disease.

Bicheng Xie, Anxing Zhang, Canmei Li, Yu Liu, Yao Deng, Ruochang Li, Haichun Qin, Bian Wu, Tian He, Danfeng Lan

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Article in Immunologic research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bicheng Xie *Department of Gastroenterology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Yunnan Digestive Disease Clinical Medical Center, No. 157, Jingbi Road, Kunming, 650032, Yunnan, China.
Anxing Zhang *Department of Gastroenterology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Yunnan Digestive Disease Clinical Medical Center, No. 157, Jingbi Road, Kunming, 650032, Yunnan, China.
Canmei Li *Department of Oncology, Dali Bai Autonomous Prefecture People's Hospital, Dali, 671000, Yunnan, China.
Yu LiuDepartment of Gastroenterology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Yunnan Digestive Disease Clinical Medical Center, No. 157, Jingbi Road, Kunming, 650032, Yunnan, China.
Yao DengDepartment of Gastroenterology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Yunnan Digestive Disease Clinical Medical Center, No. 157, Jingbi Road, Kunming, 650032, Yunnan, China.
Ruochang LiDepartment of Gastroenterology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Yunnan Digestive Disease Clinical Medical Center, No. 157, Jingbi Road, Kunming, 650032, Yunnan, China.
Haichun QinDepartment of Gastroenterology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Yunnan Digestive Disease Clinical Medical Center, No. 157, Jingbi Road, Kunming, 650032, Yunnan, China.
Bian WuDepartment of General Surgery II, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Yunnan Key Laboratory of Innovative Application of Traditional Chinese Medicine, No. 157, Jingbi Road, Kunming, 650032, Yunnan, China. 6026170@qq.com.
Tian HeDepartment of Gastroenterology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Yunnan Digestive Disease Clinical Medical Center, No. 157, Jingbi Road, Kunming, 650032, Yunnan, China. hetianyn@163.com.
Danfeng LanDepartment of Gastroenterology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Yunnan Digestive Disease Clinical Medical Center, No. 157, Jingbi Road, Kunming, 650032, Yunnan, China. ang778@live.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sorting nexin 10 (SNX10) expression induces intestinal barrier dysfunction and inflammatory responses; in contrast, its inhibition promotes intestinal mucosal healing through sterol regulatory element-binding protein 2 (SREBP2)-mediated cholesterol synthesis. However, its regulatory mechanism for the pathogenesis of inflammatory bowel disease (IBD) remains unclear. In this study, we examined SNX10 and SREBP2 expression in ulcerative colitis (UC) and Crohn's disease (CD). A total of 30 and 28 patients with UC and CD, respectively, were recruited. The expression of SNX10 and SREBP2 in the colonic mucosa was measured by immunohistochemistry (IHC). We discovered that patients with CD had significantly higher expression levels of SNX10 and SREBP2 than patients with UC and healthy controls. In addition, the expression of SREBP2 in patients with UC was significantly higher than that in healthy controls. In our study, we indicated that SNX10 and SREBP2 may serve as biomarkers for identifying patients with UC and CD, thereby providing a clinical therapeutic strategy for the treatment of IBD by inhibiting SNX10.

Indexed as

Colitis, UlcerativeIntestinal MucosaSorting NexinsSterol Regulatory Element Binding Protein 2AdultBiomarkersCrohn DiseaseFemaleHumansImmunohistochemistryInflammatory Bowel DiseasesMaleMiddle AgedYoung AdultBiomarkersSNX10 protein, humanSorting NexinsSREBF2 protein, humanSterol Regulatory Element Binding Protein 2Inflammatory bowel diseasePathogenesisSorting nexin 10Sterol regulatory element–binding protein 2

Identifiers

PMID39412576

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.