Evidence map›Paper›PMID 39412545›Full record

ArticleCalcified tissue international2024

High SHBG and Low Bioavailable Testosterone are Strongly Causally Associated with Increased Forearm Fracture Risk in Women: An MR Study Leveraging Novel Female-Specific Data.

Johan Quester, Maria Nethander, Eivind Coward, Ene Reimann, Reedik Mägi, Estonian Biobank Research Team, Ulrika Pettersson-Kymmer, Kristian Hveem, Claes Ohlsson

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Article in Calcified tissue international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Johan QuesterDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. johan.quester@gu.se.ORCID 0000-0002-7511-2846
Maria NethanderDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Eivind CowardHUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, 7491, Trondheim, Norway.
Ene ReimannEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Reedik MägiEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Estonian Biobank Research Team
Ulrika Pettersson-KymmerDepartment of Medical and Translational Biology, Clinical Pharmacology, Umea University, Umea, Sweden.
Kristian HveemHUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, 7491, Trondheim, Norway.
Claes OhlssonDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Funding

IngaBritt och Arne Lundbergs Forskningsstiftelse LU2017-0081IngaBritt och Arne Lundbergs Forskningsstiftelse LU2021-0096Knut och Alice Wallenbergs Stiftelse KAW2015.0317Novo Nordisk Fonden NNF 190C0055250the Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement ALFGBG-720331the Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement ALFGBG-965235Vetenskapsrådet 2016-01001Vetenskapsrådet 2020-01392
6 · The paper itself

Abstract

The effects of androgens on women's bone health are not fully understood. Mendelian randomization (MR) studies using sex-combined data suggest that sex hormone-binding globulin (SHBG) and bioavailable testosterone (BioT) causally affect bone traits. Given significant sex differences in hormone regulation and effects, female-specific MR studies are necessary. In the current study, we explored the causal relationships of SHBG, BioT, and total testosterone (TT) with forearm fracture (FAFx) risk in women using two-sample MR analyses. We utilized a unique female-specific FAFx outcome dataset from three European biobanks (UFO, HUNT, Estonian Biobank) comprising 111,351 women and 8823 FAFx cases, along with female-specific genetic instruments of SHBG, BioT, and TT identified in the UK Biobank. We also assessed bone mineral density (BMD) at the forearm (FA), femoral neck (FN), and lumbar spine (LS) using female-specific GWAS data from the GEFOS consortium. High SHBG (odds ratio per standard deviation increase (OR/SD): 1.53, 95% confidence intervals (CIs): 1.34-1.75), low BioT (OR/SD: 0.77, 0.71-0.84) and low TT (OR/SD 0.90, 0.83-0.98) were causally associated with increased FAFx risk. BioT was positively, and SHBG inversely, causally associated with especially FA-BMD, but also LS-BMD and FN-BMD, while TT was only significantly positively associated with FA-BMD and LS-BMD. We propose that endogenous androgens and SHBG are important for women's bone health at distal trabecular-rich bone sites such as the distal forearm and may serve as predictors for FAFx risk.

Indexed as

Bone DensityMendelian Randomization AnalysisSex Hormone-Binding GlobulinTestosteroneAgedFemaleForearmForearm InjuriesFractures, BoneHumansMiddle AgedRisk FactorsSex Hormone-Binding GlobulinSHBG protein, humanTestosteroneBoneBone densityFemaleFracturesMendelian randomization analysisSex hormone-binding globulinTestosterone

Identifiers

PMID39412545
PMCPMC11531422

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.