ArticleEnvironmental health perspectives2024
Combined Exposure to Folate and Lead during Pregnancy and Autistic-Like Behaviors among Canadian Children from the MIREC Pregnancy and Birth Cohort.
Article in Environmental health perspectives, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prenatal metal(loid) exposure and preterm birth: a systematic review of the epidemiologic evidence.Journal of exposure science & environmental epidemiology · 2025Pooled it
- Associations of prenatal metal exposures with autism-related outcomes in the ECHO cohort.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Air Pollution Mixture and Folate Status Indicators among Pregnant Women in Canada: Maternal-Infant Research on Environmental Chemicals (MIREC) Study, 2008 to 2011.Current developments in nutrition · 2026Article
- Maternal environmental exposure and early-life health risks: The modulating role of nutritional status-A scoping review.iScience · 2026Review
- Impact of a prenatal exposure mixture of metals on DNA methylation-derived cell-type composition in cord blood.Environmental epigenetics · 2026Article
- Prenatal and childhood exposures to heavy metals and their associations with child cognition, motor skills, behaviour and mental health.Essays in biochemistry · 2025Review
- Prenatal fluoride exposure and autistic behaviors in preschool-aged children: the Maternal-Infant Research on Environmental Chemicals (MIREC) cohort study.Environmental health : a global access science source · 2025Article
- Association between gestational environmental chemical mixtures and folate exposures with autistic behaviors in a Canadian birth cohort.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- Invited Perspective: Protect and Serve-The Potential Role of Folate in Lead Risk Reduction.Environmental health perspectives · 2024Article
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Authors and funding
11 authors.
Funding
Abstract
backgroundFolic acid (FA) supplementation may attenuate the associations between gestational exposure to certain chemicals and autism or autistic-like behaviors, but to our knowledge, this has not been assessed for lead.
objectivesWe examined whether the relationship between gestational blood-lead levels (BLLs) and autistic-like behaviors was modified by gestational plasma total folate concentrations, FA supplementation, and maternal methylenetetrahydrofolate reductase (
methodsWe used data from the Maternal-Infant Research on Environmental Chemicals study (2008-2011), a Canadian pregnancy and birth cohort study. Childhood autistic-like behaviors were documented in 601 children 3-4 y of age with the Social Responsiveness Scale-2 (SRS-2), where higher scores denote more autistic-like behaviors. We measured BLLs and plasma total folate concentrations during the first and third trimesters of pregnancy. We also estimated gestational FA supplementation via surveys and genotyped the maternal
resultsThird-trimester BLLs were associated with increased SRS-2 scores [ DISCUSSION: Folate may modify the associations between gestational lead exposure and childhood autistic-like behaviors, suggesting that it mitigates the neurotoxic effects of prenatal lead exposure. https://doi.org/10.1289/EHP14479.
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