Evidence map›Paper›PMID 39412256›Full record

ArticleJournal of virology2024

Human metapneumovirus SH protein promotes JAK1 degradation to impair host IL-6 signaling.

Adam Brynes, Yu Zhang, John V Williams

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. The regulatory roles of STAT3 protein in the pathogenesis of viral infections.Frontiers in cellular and infection microbiology · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Adam BrynesProgram in Microbiology and Immunology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-2367-8848
Yu ZhangDepartment of Pediatrics, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
John V WilliamsDepartment of Pediatrics, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-8377-5175

Funding

Host Determinants of Human Metapneumovirus Immunity and PathogenesisR01AI085062 · NIAID · VANDERBILT UNIVERSITY · PI John V. Williams · 2010 to 2026
$5.6M
Viral Persistence and PathogenesisT32AI049820 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DELUCA, NEAL A. · 2001 to 2024
$5.5M
Henry L. Hillman FoundationHHS | National Institutes of Health (NIH) AI-049820HHS | National Institutes of Health (NIH) AI085062NIAID NIH HHS R01 AI085062NIAID NIH HHS T32 AI049820
6 · The paper itself

Abstract

Human metapneumovirus (HMPV) is a leading cause of respiratory infections in children, older adults, and those with underlying conditions (K. M. Edwards et al., N Engl J Med 368:633-643, 2013, https://doi.org/10.1056/NEJMoa1204630; A. R. Falsey et al., J Infect Dis 187:785-790, 2003, https://doi.org/10.1086/367901; J. S. Kahn, Clin Microbiol Rev 19:546-557, 2006, https://doi.org/10.1128/CMR.00014-06; N. Shafagati and J. Williams, F1000Res 7:135, 2018, https://doi.org/10.12688/f1000research.12625.1). HMPV must evade immune defenses to replicate successfully; however, the viral proteins used to accomplish this are poorly characterized. The HMPV small hydrophobic (SH) protein has been reported to inhibit signaling through type I and type II interferon (IFN) receptors

Indexed as

Interleukin-6Janus Kinase 1MetapneumovirusParamyxoviridae InfectionsSignal TransductionViral ProteinsCell LineHEK293 CellsHost-Pathogen InteractionsHumansProteolysisRetroviridae Proteins, OncogenicSTAT1 Transcription FactorVirus ReplicationIL6 protein, humanInterleukin-6JAK1 protein, humanJanus Kinase 1Retroviridae Proteins, Oncogenicsmall hydrophobic protein, virusSTAT1 Transcription FactorViral ProteinsHMPVhuman metapneumovirusinnate immunityinterferonsPneumoviridaeproteasomevirology

Identifiers

PMID39412256
PMCPMC11575145

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.