Evidence map›Paper›PMID 39412000›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

The role of leukocytes in cognitive impairment due to long-term exposure to fine particulate matter: A large population-based mediation analysis.

Benjamin Aretz, Gabriele Doblhammer, Michael T Heneka

Abstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Benjamin AretzInstitute of Sociology and Demography, University of Rostock, Rostock, Mecklenburg-Vorpommern, Germany.ORCID 0000-0003-0143-0873
Gabriele DoblhammerInstitute of Sociology and Demography, University of Rostock, Rostock, Mecklenburg-Vorpommern, Germany.ORCID 0000-0001-7746-0652
Michael T HenekaLuxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Esch-sur-Alzette, Luxembourg.ORCID 0000-0003-4996-1630

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOur understanding of how fine particulate matter (PM

methodsThis prospective cohort study used data from 66,254 participants aged 18+ between 2006 and 2015 from the Dutch Lifelines Cohort Study and Biobank. Causal mediation analysis was conducted to examine the impact of ambient PM

resultsHeightened PM DISCUSSION: Systemic inflammation processes may partially explain the harmful effects of PM HIGHLIGHTS: The pathways leading to the neurotoxic effects of fine particulate matter (PM

Indexed as

Cognitive DysfunctionEnvironmental ExposureLeukocytesMediation AnalysisParticulate MatterAdultAgedAir PollutantsAir PollutionCohort StudiesFemaleHumansInflammationLeukocyte CountMaleMiddle AgedAir PollutantsParticulate Mattercausal mediation analysiscognitive functioningfine particulate matterleukocytessystemic inflammationwhite blood cell count

Identifiers

PMID39412000
PMCPMC11667545

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.