Evidence map›Paper›PMID 39411959›Full record

ArticleCurrent pharmaceutical biotechnology2025

Preparation and Characterization of Universal Liquid Proliposomes Encapsulating Water-soluble Efficacious Substances.

Li Xu, Zhaohe Huang, Xiaojing Pei, Ze Zhang, Shujing Li, Yifan He

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Article in Current pharmaceutical biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Li XuInstitute of Regulatory Science, School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing, 100048, P.R. China.
Zhaohe HuangInstitute of Regulatory Science, School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing, 100048, P.R. China.
Xiaojing PeiInstitute of Regulatory Science, School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing, 100048, P.R. China.
Ze ZhangInstitute of Regulatory Science, School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing, 100048, P.R. China.
Shujing LiInstitute of Regulatory Science, School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing, 100048, P.R. China.
Yifan HeInstitute of Regulatory Science, School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing, 100048, P.R. China.

Funding

National Natural Science Foundation of China 22004005
6 · The paper itself

Abstract

introductionLiposomes were extensively used for cosmetics and pharmaceuticals due to their versatility, biocompatibility, and biodegradability, as well as the ability to encapsulate water-soluble and fat-soluble substances. However, some challenges remain unsolved, including poor stability, complex preparation process, limited encapsulation efficiencies (EE%) and drug loading capacity (DLC%).

methodsWe herein prepared universal liquid proliposomes by rotary evaporation method and optimized formulations with different pH, glycerol content, ethanol content and preparation process.

resultsThe EE% of water-soluble substances was above 85%, and the maximum DLC% was 37.5%. In 7 different conditions, the optimal formulation of the proliposomes remained stable over 60 days. The excellent stability of proliposomes and nicotinamide liposomes and their essence, when applied to cosmetic formulations, was confirmed by the Turbiscan stability analyzer.

conclusionThe proposed universal liquid proliposomes can form liposomes encapsulating a variety of water-soluble substances rapidly, making them an accessible and versatile tool for improving the stability and applicability of water-soluble raw materials.

Indexed as

LiposomesChemistry, PharmaceuticalCosmeticsDrug CompoundingDrug StabilityGlycerolHydrogen-Ion ConcentrationNiacinamideSolubilityWaterCosmeticsGlycerolLiposomesNiacinamideWaterdrug loading capacityencapsulation efficiencyLiquid proliposomesstabilityturbiscan stability.water-soluble functional substances

Identifiers

PMID39411959

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