Evidence map›Paper›PMID 39411681›Full record

ArticleTropical parasitology

Free-living amoebic encephalitis - Case series.

Sithara Nasar Thottathil Puthanpurayil, Aiswarya Mukundan, Suryakala Ravi Nair, Anu Pudurkara John, Mithuna Rohini Thampi, Reena John, Rakesh Sehgal

Abstract read
In one paragraph

Article in Tropical parasitology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Global Review onInfectious disease reports · 2026
    Review
  3. Article
  4. Article
  5. Journal of clinical medicine · 2025
    Review
  6. Review
  7. Free-living amoebae.Tropical parasitology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sithara Nasar Thottathil PuthanpurayilDepartment of Microbiology, Government Medical College, Thrissur, Kerala, India.
Aiswarya MukundanDepartment of Microbiology, Government Medical College, Thrissur, Kerala, India.
Suryakala Ravi NairDepartment of Microbiology, Government Medical College, Thrissur, Kerala, India.
Anu Pudurkara JohnDepartment of Microbiology, Government Medical College, Thrissur, Kerala, India.
Mithuna Rohini ThampiDepartment of Microbiology, Government Medical College, Thrissur, Kerala, India.
Reena JohnDepartment of Microbiology, Government Medical College, Thrissur, Kerala, India.
Rakesh SehgalAarupadai Veedu Medical College and Hospital, Vinayaka Mission's Research Foundation-DU, Puducherry, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Free-living amoeba is ubiquitous in fresh water, mud, and moist soil; although seldom pathogenic to humans, Methods: We report two interesting cases, both of which presented with a rapid-onset and fulminant course. The first case details a 36-year-old male with a history of surgically corrected nasal bone fracture 15 years back, who presented with acute onset of fever, headache and convulsions. Results: Direct smears of cerebrospinal fluid (CSF) revealed motile trophozoites resembling Conclusion: Rapid progression and lack of definite treatment options make this a highly fatal condition. Although clinical presentations of both patients were indicative of pyogenic meningitis, parasitic infection was suspected when the CSF was found turbid with no bacteria, high protein, and low sugar. High index of suspicion helped us to get an early preliminary diagnosis from direct microscopy.

Indexed as

Acanthamoebafree-living amoebaNaegleria

Identifiers

PMID39411681
PMCPMC11473018

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.