Evidence map›Paper›PMID 39411535›Full record

ArticleACS medicinal chemistry letters2024

Enhanced Plasma Stability and Potency of Aryl/Acyloxy Prodrugs of a BTN3A1 Ligand.

Umed Singh, Girija Pawge, Sarita Rani, Chia-Hung Christine Hsiao, David F Wiemer, Andrew J Wiemer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Umed SinghDepartment of Chemistry, University of Iowa, Iowa City, Iowa 52242-1294, United States.
Girija PawgeDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269-3092, United States.
Sarita RaniDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269-3092, United States.
Chia-Hung Christine HsiaoDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269-3092, United States.ORCID https://orcid.org/0000-0002-9037-027X
David F WiemerDepartment of Chemistry, University of Iowa, Iowa City, Iowa 52242-1294, United States.ORCID https://orcid.org/0000-0002-4881-8544
Andrew J WiemerDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269-3092, United States.ORCID https://orcid.org/0000-0002-3029-1780

Funding

Role of immune modulating butyrophilins in gamma delta T cell activationR01AI150869 · NIAID · UNIVERSITY OF CONNECTICUT STORRS · PI VINOGRADOVA, OLGA, WIEMER, ANDREW J · 2020 to 2024
$2.0M
Synthesis and evaluation of BTN3A1 ligands for cancer immunotherapyR01CA266138 · NCI · UNIVERSITY OF CONNECTICUT STORRS · PI ANDREW J WIEMER · 2022 to 2026
$1.8M
NCI NIH HHS R01 CA266138NIAID NIH HHS R01 AI150869
6 · The paper itself

Abstract

While ester-based phosphonate prodrugs excel at delivering payloads into cells, their instability in plasma is a hurdle for their advancement. Here, we synthesized new aryl/acyloxy prodrugs of a phosphonate BTN3A1 ligand. We evaluated their phosphoantigen potency by flow cytometry and ELISA and their plasma and cellular metabolism by LC-MS. These compounds displayed low nanomolar to high picomolar potency. Addition of a

Identifiers

PMID39411535
PMCPMC11472817

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.