Evidence map›Paper›PMID 39411531›Full record

ArticleACS medicinal chemistry letters2024

Exploring the 1-(4-Nitrophenyl)-3-arylprop-2-en-1-one Scaffold for the Selective Inhibition of Monoamine Oxidase B.

Rita Meleddu, Antonella Fais, Benedetta Era, Sonia Floris, Simona Distinto, Antonio Lupia, Filippo Cottiglia, Alessia Onali, Erica Sanna, Daniela Secci and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Rita MeledduDepartment of Life and Environmental Sciences, University of Cagliari, University Campus, S.P. 8 km 0.700, 09042 Monserrato, Italy.ORCID https://orcid.org/0000-0003-1629-7454
Antonella FaisDepartment of Life and Environmental Sciences, University of Cagliari, University Campus, S.P. 8 km 0.700, 09042 Monserrato, Italy.ORCID https://orcid.org/0000-0002-3009-4226
Benedetta EraDepartment of Life and Environmental Sciences, University of Cagliari, University Campus, S.P. 8 km 0.700, 09042 Monserrato, Italy.
Sonia FlorisDepartment of Life and Environmental Sciences, University of Cagliari, University Campus, S.P. 8 km 0.700, 09042 Monserrato, Italy.
Simona DistintoDepartment of Life and Environmental Sciences, University of Cagliari, University Campus, S.P. 8 km 0.700, 09042 Monserrato, Italy.ORCID https://orcid.org/0000-0003-1620-6225
Antonio LupiaDepartment of Life and Environmental Sciences, University of Cagliari, University Campus, S.P. 8 km 0.700, 09042 Monserrato, Italy.ORCID https://orcid.org/0000-0003-0870-2376
Filippo CottigliaDepartment of Life and Environmental Sciences, University of Cagliari, University Campus, S.P. 8 km 0.700, 09042 Monserrato, Italy.ORCID https://orcid.org/0000-0003-4659-9808
Alessia OnaliDepartment of Life and Environmental Sciences, University of Cagliari, University Campus, S.P. 8 km 0.700, 09042 Monserrato, Italy.ORCID https://orcid.org/0009-0004-7540-3901
Erica SannaDepartment of Life and Environmental Sciences, University of Cagliari, University Campus, S.P. 8 km 0.700, 09042 Monserrato, Italy.ORCID https://orcid.org/0009-0001-4895-970X
Daniela SecciDepartment of Life and Environmental Sciences, University of Cagliari, University Campus, S.P. 8 km 0.700, 09042 Monserrato, Italy.
Giulia AtzeniDepartment of Life and Environmental Sciences, University of Cagliari, University Campus, S.P. 8 km 0.700, 09042 Monserrato, Italy.ORCID https://orcid.org/0009-0005-1519-5431
Laura DemuruDepartment of Life and Environmental Sciences, University of Cagliari, University Campus, S.P. 8 km 0.700, 09042 Monserrato, Italy.ORCID https://orcid.org/0009-0006-2424-3789
Pierluigi CaboniDepartment of Life and Environmental Sciences, University of Cagliari, University Campus, S.P. 8 km 0.700, 09042 Monserrato, Italy.ORCID https://orcid.org/0000-0003-2448-3767
Donatella ValentiDepartment of Life and Environmental Sciences, University of Cagliari, University Campus, S.P. 8 km 0.700, 09042 Monserrato, Italy.
Elias MaccioniDepartment of Life and Environmental Sciences, University of Cagliari, University Campus, S.P. 8 km 0.700, 09042 Monserrato, Italy.ORCID https://orcid.org/0000-0003-2175-2802

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A small library of 1-(4-nitrophenyl)-3-arylprop-2-en-1-one derivatives was synthesized to identify new human monoamine oxidase B selective inhibitors. Their inhibitory activity toward MAO-A and MAO-B isoforms was evaluated to determine their potency and selectivity. All newly synthesized compounds were nanomolar inhibitors of the B isoform with IC

Identifiers

PMID39411531
PMCPMC11472546

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.