Evidence map›Paper›PMID 39411470›Full record

ArticleJCPP advances2024

Attentional development is altered in toddlers with congenital heart disease.

Alexandra F Bonthrone, Vanessa Kyriakopoulou, Luke Mason, Andrew Chew, Shona Falconer, Christopher J Kelly, John Simpson, Kuberan Pushparajah, Mark H Johnson, A David Edwards and 3 more

Abstract read
In one paragraph

Article in JCPP advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alexandra F BonthroneCentre for the Developing Brain School of Biomedical Engineering and Imaging Sciences King's College London London UK.ORCID https://orcid.org/0000-0001-5487-5564
Vanessa KyriakopoulouCentre for the Developing Brain School of Biomedical Engineering and Imaging Sciences King's College London London UK.
Luke MasonDepartment of Forensic and Neurodevelopmental Sciences Institute of Psychiatry Psychology & Neuroscience King's College London London UK.
Andrew ChewCentre for the Developing Brain School of Biomedical Engineering and Imaging Sciences King's College London London UK.
Shona FalconerCentre for the Developing Brain School of Biomedical Engineering and Imaging Sciences King's College London London UK.
Christopher J KellyCentre for the Developing Brain School of Biomedical Engineering and Imaging Sciences King's College London London UK.
John SimpsonPaediatric Cardiology Department Evelina London Children's Healthcare London UK.
Kuberan PushparajahPaediatric Cardiology Department Evelina London Children's Healthcare London UK.
Mark H JohnsonDepartment of Psychology University of Cambridge Cambridge UK.
A David EdwardsCentre for the Developing Brain School of Biomedical Engineering and Imaging Sciences King's College London London UK.ORCID https://orcid.org/0000-0003-4801-7066
Chiara NosartiCentre for the Developing Brain School of Biomedical Engineering and Imaging Sciences King's College London London UK.ORCID https://orcid.org/0000-0001-6305-9710
Emily J H JonesDepartment of Psychological Sciences Centre for Brain and Cognitive Development Birkbeck University of London London UK.ORCID https://orcid.org/0000-0001-5747-9540
Serena J CounsellCentre for the Developing Brain School of Biomedical Engineering and Imaging Sciences King's College London London UK.ORCID https://orcid.org/0000-0002-8033-5673

Funding

Wellcome Trust
6 · The paper itself

Abstract

Background: Congenital Heart Disease (CHD) is the most common congenital abnormality. Survival rates are over 90%, however infants with CHD remain at high risk of attention and executive function impairments. These abilities are difficult to assess in toddlers because clinical assessments rely on language abilities which are commonly delayed in CHD. Our aim was to characterise visual attention in toddlers with CHD compared to controls and identify associations with parent-rated effortful control. Methods: Thirty toddlers with CHD (19 male, median (IQR) age at assessment 22.2 (22-23.1) months) and 66 controls from the developing human connectome project (36 male, age at assessment 22 (21.5-23.8) months) using eye-tracking tasks designed to assess multiple components of visual attention. Analyses of co-variance and regressions were used to identify differences between groups and relationships between gaze behaviours and parent-rated effortful control. Results: Toddlers with CHD were less accurate when switching behaviours (set-shifting) [median (IQR) 79%, (28-100)] compared to controls [100% (86-100), pFDR = 0.032], with worse accuracy associated with lower parent-rated effortful control in CHD but not controls (interaction pFDR = 0.028). Reaction times were slower during selective [CHD 1243 ms (986-1786), controls 1065 ms (0851-1397), pFDR<0.001] and exogenous attention tasks [CHD 312 ms (279-358), control 289 (249-331), (pFDR = 0.032) and endogenous attention was less mature (prolonged looks at facial stimuli CHD 670 ms (518-885), control 500 ms (250-625), (pFDR = 0.006). These results were unrelated to differences in cognition or socioeconomic status. In contrast, the allocation of attentional resources was preserved in CHD. Conclusions: We identified a profile of altered attention and early executive functioning development in CHD. Eye-tracking may provide clinically feasible, early objective measures of attention and executive function development in CHD.

Indexed as

congenital heart diseaseexecutive functionseye‐trackingvisual attention

Identifiers

PMID39411470
PMCPMC11472800

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.