Evidence map›Paper›PMID 39411371›Full record

ArticleFrontiers in genetics2024

MicroRNA binding site variants-new potential markers of primary osteoporosis in men and women.

Bulat Yalaev, Roman Deev, Anton Tyurin, Ramil Salakhov, Kirill Smirnov, Anna Eremkina, Natalia Mokrysheva, Ildar Minniakhmetov, Rita Khusainova

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In one paragraph

Article in Frontiers in genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bulat YalaevLaboratory of Genomic Medicine, Endocrinology Research Centre, Moscow, Russia.
Roman DeevLaboratory of Genomic Medicine, Endocrinology Research Centre, Moscow, Russia.
Anton TyurinInternal Medicine Department, Bashkir State Medical University, Ufa, Russia.
Ramil SalakhovLaboratory of Genomic Medicine, Endocrinology Research Centre, Moscow, Russia.
Kirill SmirnovLaboratory of Genomic Medicine, Endocrinology Research Centre, Moscow, Russia.
Anna EremkinaLaboratory of Genomic Medicine, Endocrinology Research Centre, Moscow, Russia.
Natalia MokryshevaLaboratory of Genomic Medicine, Endocrinology Research Centre, Moscow, Russia.
Ildar MinniakhmetovLaboratory of Genomic Medicine, Endocrinology Research Centre, Moscow, Russia.
Rita KhusainovaLaboratory of Genomic Medicine, Endocrinology Research Centre, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The identification of significant DNA markers of primary osteoporosis may gain new insights by studying genome regions involved in mechanisms of epigenetic regulation through interactions with microRNAs. Methods: The authors searched for associations of polymorphic variants of microRNA binding sites of mRNA target genes and polymorphic loci of microRNA genes with primary osteoporosis in a cohort of women and men from the Volga-Ural region of Russia (N = 1.177). Results: Using case-control association analysis, the authors found that rs1061947 (

Indexed as

femoral neckfracturesmicroRNA binding sitesosteoporosisradial bonespine

Identifiers

PMID39411371
PMCPMC11473367

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.