ReviewNational science review2024
Engineered Janus hydrogels: biomimetic surface engineering and biomedical applications.
Review in National science review, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Bioactive 3D-Printed valve scaffold promoting valvular regeneration via immunomodulation and endothelialization.Bioactive materials · 2026Article
- 3D-Printed Bioadhesive Interfaces as Proliferative Niches for Tissue Repair.Cell proliferation · 2026Review
- Next-Generation Hydrogel Skin Adhesives: From Bioinspired Adhesion Chemistry to Regenerative Wound Interfaces.Advanced healthcare materials · 2026Review
- An Ionically Crosslinked Hyperelastic Hydrogel With Extreme Environmental Tolerance and Self-Strengthening Capability.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Oral hydrogel systems in lower gastrointestinal disorders: From disease-based therapy to microbiota-guided design.Materials today. Bio · 2026Review
- Skin-mimetic bilayer hydrogel enhances spatiotemporal coordination of neuro-immune-vascular interactions to accelerate diabetic wound healing.Bioactive materials · 2026Article
- Hydrogel Adhesives for Gastrointestinal Perforation: Design Principles and Applications.Exploration (Beijing, China) · 2026Review
- Spermidine-functionalized Janus hydrogel microneedles inhibit ferroptosis and promote healing of oral ulcers.Bioactive materials · 2026Article
- Nature-Inspired Solutions: Biomimetic Materials and Adaptive Devices for Precision Urinary Oncology.Cancers · 2026Review
- Microenvironment engineering with injectable hydrogel-based biofunctional scaffolds for augmenting bone defect regeneration.Journal of nanobiotechnology · 2026Review
- Highly Sensitive Oxidation-Resistant Degradable Janus Piezoresistive Electronic Skin for Sustainable Wearable Electronics.Advanced healthcare materials · 2026Article
- Hierarchical picot-fiber hydrogel coating with ultralow friction and high wear resistance.Nature communications · 2026Article
- Molecular competition induced Janus hydrogel bioelectronic interface for electroceutical modulation.Nature communications · 2025Article
- Hydrogel Films in Biomedical Applications: Fabrication, Properties and Therapeutic Potential.Gels (Basel, Switzerland) · 2025Review
- Janus Hydrogels: Design, Properties, and Applications.Gels (Basel, Switzerland) · 2025Review
- Multifunctional Janus Hydrogels: Surface Design Strategies for Next-Generation Clinical Solutions.Gels (Basel, Switzerland) · 2025Review
- A Dual-Layer Hydrogel Barrier Integrating Bio-Adhesive and Anti-Adhesive Properties Prevents Postoperative Abdominal Adhesions.Advanced healthcare materials · 2025Article
- A bibliometric analysis of hydrogel research in various fields: the trends and evolution of hydrogel application.Journal of nanobiotechnology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydrogel bioadhesives, when applied to dysfunctional tissues substituting the epidermis or endothelium, exhibit compelling characteristics that enable revolutionary diagnostic and therapeutic procedures. Despite their demonstrated efficacy, these hydrogels as soft implants are still limited by improper symmetric surface functions, leading to postoperative complications and disorders. Janus hydrogel bioadhesives with unique asymmetric surface designs have thus been proposed as a reliable and biocompatible hydrogel interface, mimicking the structural characteristics of natural biological barriers. In this comprehensive review, we provide guidelines for the rational design of Janus hydrogel bioadhesives, covering methods for hydrogel surface chemistry and microstructure engineering. The engineering of Janus hydrogels is highlighted, specifically in tuning the basal surface to facilitate instant and robust hydrogel-tissue integration and modulating the apical surface as the anti-adhesion, anti-fouling, and anti-wear barrier. These asymmetric designs hold great potential in clinical translation, supporting applications including hemostasis/tissue sealing, chronic wound management, and regenerative medicine. By shedding light on the potential of Janus hydrogels as bioactive interfaces, this review paper aims to inspire further research and overcome current obstacles for advancing soft matter in next-generation healthcare.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.