Evidence map›Paper›PMID 39411322›Full record

ArticleFrontiers in cellular and infection microbiology2024

Shila Kumari Singh, Minakshi Bhattacharjee, Balagopalan Unni, Rajpal Singh Kashyap, Abdul Malik, Suhail Akhtar, Sabiha Fatima

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shila Kumari SinghFaculty of Sciences, Assam Downtown University, Guwahati, Assam, India.
Minakshi BhattacharjeeFaculty of Sciences, Assam Downtown University, Guwahati, Assam, India.
Balagopalan UnniFaculty of Sciences, Assam Downtown University, Guwahati, Assam, India.
Rajpal Singh KashyapDepartment of Research, Central India Institute of Medical Science, Nagpur, Maharasthra, India.
Abdul MalikCollege of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Suhail AkhtarDepartment of Biochemistry, Andrew Taylor Still University of Health Science, Kirksville, MO, United States.
Sabiha FatimaCollege of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: In this study, we identified a compound that acts as an antagonist of ClfA and ClfB by inhibiting their binding to host cells. Results: The shortlisted compound's binding activity was tested by docking and molecular dynamics during its interaction with proteins. The identified compound has excellent binding energy with both ClfA (-10.11 kcal/mol) and ClfB (-11.11 kcal/mol). Discussion: The molecular dynamics of the protein and compound were stable and promising for further

Indexed as

Anti-Bacterial AgentsCoagulaseMolecular Docking SimulationMolecular Dynamics SimulationProtein BindingStaphylococcal InfectionsStaphylococcus aureusAdhesins, BacterialComputer SimulationDrug DiscoveryHumansVirulence FactorsAdhesins, BacterialAnti-Bacterial AgentsClfA protein, Staphylococcus aureusclfB protein, Staphylococcus aureusCoagulaseVirulence Factorsadhesin binding proteinantimicrobial resistance (AMR)clumping factorcolonizationmolecular docking & molecular dynamics (MD) simulationStaphylococcus aureus

Identifiers

PMID39411322
PMCPMC11475578

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.