ArticleFrontiers in pediatrics2024
Structural development and brain asymmetry in the fronto-limbic regions in preschool-aged children.
Article in Frontiers in pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Functional Brain Asymmetry Reveals Heterogeneous Subtypes in Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2026Article
- Associations Between Nutritional Status, Cognitive Performance, and Surrogate Metabolic Profiles in School-Aged Children.Nutrients · 2026Article
- Annual Trends in Suicide Among Children Under 13 Years in South Korea, 2013-2022: Based on the Intentional Self-Harm (Suicide) Report of Statistics Korea.JAACAP open · 2026Article
- Morphological changes and lateralization of the thalamic nuclei in children with growth hormone deficiency.Frontiers in endocrinology · 2025Article
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8 authors.
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Abstract
Early-life experiences play a crucial role in the development of the fronto-limbic regions, influencing both macro- and microstructural changes in the brain. These alterations profoundly impact cognitive, social-emotional functions. Recently, early limbic structural alterations have been associated with numerous neurological and psychiatric morbidities. Although identifying normative developmental trajectories is essential for determining brain alterations, only a few studies have focused on examining the normative trajectories in the fronto-limbic regions during preschool-aged children. The aim of this study was to investigate the structural-developmental trajectory of the fronto-limbic regions using the cortical thickness, volume, and subcortical volume in 57 healthy and typical preschool-aged children between 1 and 5 years and examined the early lateralization patterns during the development of the fronto-limbic regions. Regarding brain lateralization, remarkable asymmetry was detected in the volume of thalamus and the cortical regions excluding the lateral orbitofrontal cortex in the fronto-limbic regions. This study of preschool-aged children may fill the knowledge gaps regarding the developmental patterns and hemispheric asymmetries of the fronto-limbic regions between newborns and adolescents.
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