Evidence map›Paper›PMID 39411258›Full record

ArticleRSC advances2024

Dual nanofiber and graphene reinforcement of 3D printed biomimetic supports for bone tissue repair.

Elena Cojocaru, Mădălina Oprea, George Mihail Vlăsceanu, Mădălina-Cristina Nicolae, Roxana-Cristina Popescu, Paul-Emil Mereuţă, Alin-Georgian Toader, Mariana Ioniţă

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elena CojocaruAdvanced Polymer Materials Group, National University of Science and Technology POLITEHNICA Bucharest 1-7 Gh. Polizu Street Bucharest 011061 Romania mariana.ionita@polimi.it.ORCID https://orcid.org/0000-0001-7783-7210
Mădălina OpreaAdvanced Polymer Materials Group, National University of Science and Technology POLITEHNICA Bucharest 1-7 Gh. Polizu Street Bucharest 011061 Romania mariana.ionita@polimi.it.ORCID https://orcid.org/0000-0002-8050-6815
George Mihail VlăsceanuAdvanced Polymer Materials Group, National University of Science and Technology POLITEHNICA Bucharest 1-7 Gh. Polizu Street Bucharest 011061 Romania mariana.ionita@polimi.it.ORCID https://orcid.org/0000-0002-9876-6180
Mădălina-Cristina NicolaeAdvanced Polymer Materials Group, National University of Science and Technology POLITEHNICA Bucharest 1-7 Gh. Polizu Street Bucharest 011061 Romania mariana.ionita@polimi.it.ORCID https://orcid.org/0000-0002-5900-1345
Roxana-Cristina PopescuFaculty of Medical Engineering, National University of Science and Technology POLITEHNICA Bucharest 1-7 Gh. Polizu Street Bucharest 011061 Romania.ORCID https://orcid.org/0000-0003-0815-8243
Paul-Emil MereuţăNational Institute for Research and Development in Physics and Nuclear Engineering "Horia Hulubei", Department of Applied Nuclear Physics 30 Reactor. Street Magurele Romania.ORCID https://orcid.org/0000-0002-9911-4766
Alin-Georgian ToaderAdvanced Polymer Materials Group, National University of Science and Technology POLITEHNICA Bucharest 1-7 Gh. Polizu Street Bucharest 011061 Romania mariana.ionita@polimi.it.ORCID https://orcid.org/0009-0002-3858-8447
Mariana IoniţăAdvanced Polymer Materials Group, National University of Science and Technology POLITEHNICA Bucharest 1-7 Gh. Polizu Street Bucharest 011061 Romania mariana.ionita@polimi.it.ORCID https://orcid.org/0000-0002-9563-7148

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Replicating the intricate architecture of the extracellular matrix (ECM) is an actual challenge in the field of bone tissue engineering. In the present research study, calcium alginate/cellulose nanofibrils-based 3D printed scaffolds, double-reinforced with chitosan/polyethylene oxide electrospun nanofibers (NFs) and graphene oxide (GO) were prepared using the 3D printing technique. The porous matrix was provided by the calcium alginate, while the anisotropy degree and mechanical properties were ensured by the addition of fillers with different sizes and shapes (CNFs, NFs, GO), similar to the components naturally found in bone ECM. Surface morphology and 3D internal microstructure were analyzed using scanning electron microscopy (SEM) and micro-computed tomography (μ-CT), which evidenced a synergistic effect of the reinforcing and functional fibers addition, as well as of the GO sheets that seem to govern materials structuration. Also, the nanoindentation measurements showed significant differences in the elasticity and viscosity modulus, depending on the measurement point, this supported the anisotropic character of the scaffolds.

Identifiers

PMID39411258
PMCPMC11474446

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.