Evidence map›Paper›PMID 39411152›Full record

ArticleVirus evolution2024

Independent repeated mutations within the alphaviruses Ross River virus and Barmah Forest virus indicates convergent evolution and past positive selection in ancestral populations despite ongoing purifying selection.

Alyssa T Pyke, Daniel J Wilson, Alice Michie, John S Mackenzie, Allison Imrie, Jane Cameron, Stephen L Doggett, John Haniotis, Lara J Herrero, Leon Caly and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virus evolution, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Alyssa T PykePublic Health Virology Laboratory, Public and Environmental Health Reference Laboratories, Department of Health, Queensland Government, P.O. Box 594, Archerfield, Coopers Plains, Queensland, Australia.ORCID https://orcid.org/0000-0003-3512-4321
Daniel J WilsonBig Data Institute, Oxford Population Health, University of Oxford, Li Ka Shing Centre for Health Information and Discovery, Old Road Campus, Oxford OX3 7LF, United Kingdom.ORCID https://orcid.org/0000-0002-0940-3311
Alice MichieSchool of Biomedical Sciences, University of Western Australia, 35 Stirling Highway, Perth, Western Australia 6009, Australia.
John S MackenzieFaculty of Health Sciences, Curtin University, G.P.O. Box U1987, Bentley, Western Australia 6845, Australia.
Allison ImrieSchool of Biomedical Sciences, University of Western Australia, 35 Stirling Highway, Perth, Western Australia 6009, Australia.
Jane CameronPublic Health Virology Laboratory, Public and Environmental Health Reference Laboratories, Department of Health, Queensland Government, P.O. Box 594, Archerfield, Coopers Plains, Queensland, Australia.
Stephen L DoggettNSW Health Pathology, Westmead Hospital, 166-174 Hawkesbury Road Westmead, Sydney, New South Wales 2145, Australia.ORCID https://orcid.org/0000-0001-5636-627X
John HaniotisNSW Health Pathology, Westmead Hospital, 166-174 Hawkesbury Road Westmead, Sydney, New South Wales 2145, Australia.
Lara J HerreroGold Coast Campus, Institute for Glycomics, Griffith University, 1 Parklands Drive, Southport, Queensland 4215, Australia.
Leon CalyVictorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, 792 Elizabeth Street, Melbourne, Victoria 3000, Australia.
Stacey E LynchAgriculture Victoria Research, AgriBio, Centre for AgriBioscience, 5 Ring Road, Bundoora, Victoria 3083, Australia.
Peter T MeeAgriculture Victoria Research, AgriBio, Centre for AgriBioscience, 5 Ring Road, Bundoora, Victoria 3083, Australia.
Eugene T MadzokereGold Coast Campus, Institute for Glycomics, Griffith University, 1 Parklands Drive, Southport, Queensland 4215, Australia.
Ana L RamirezCollege of Public Health, Medical and Veterinary Sciences, James Cook University, P.O. Box 6811, Cairns, Queensland 4870, Australia.
Devina ParamithaSchool of Chemistry and Molecular Biosciences, The University of Queensland, Bdg 68 Cooper Road, St. Lucia, Queensland 4072, Australia.
Jody Hobson-PetersSchool of Chemistry and Molecular Biosciences, The University of Queensland, Bdg 68 Cooper Road, St. Lucia, Queensland 4072, Australia.
David W SmithNSW Health Pathology, Westmead Hospital, 166-174 Hawkesbury Road Westmead, Sydney, New South Wales 2145, Australia.
Richard WeirDepartment of Primary Industries and Fisheries, Berrimah Veterinary Laboratory, P.O. Box 3000, Darwin, Northern Territory 0801, Australia.
Mitchell SullivanPublic and Environmental Health Reference Laboratories, Department of Health, Queensland Government, P.O Box 594 Archerfield, Coopers Plains, Queensland 4108, Australia.
Julian DruceVictorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, 792 Elizabeth Street, Melbourne, Victoria 3000, Australia.
Lorna MelvilleDepartment of Primary Industries and Fisheries, Berrimah Veterinary Laboratory, P.O. Box 3000, Darwin, Northern Territory 0801, Australia.
Jennifer RobsonDepartment of Microbiology and Molecular Pathology, Sullivan Nicolaides Pathology, P.O. Box 2014 Fortitude Valley, Brisbane, Queensland 4006, Australia.
Robert GibbSerology, Pathology Queensland Central Laboratory, Royal Brisbane and Women's Hospital, 40 Butterfield Street Herston, Brisbane, Queensland 4029, Australia.
Andrew F van den HurkPublic Health Virology Laboratory, Public and Environmental Health Reference Laboratories, Department of Health, Queensland Government, P.O. Box 594, Archerfield, Coopers Plains, Queensland, Australia.ORCID https://orcid.org/0000-0001-6262-831X
Sebastian DucheneDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, 792 Elizabeth Street, Melbourne, Victoria 3000, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ross River virus (RRV) and Barmah Forest virus (BFV) are arthritogenic arthropod-borne viruses (arboviruses) that exhibit generalist host associations and share distributions in Australia and Papua New Guinea (PNG). Using stochastic mapping and discrete-trait phylogenetic analyses, we profiled the independent evolution of RRV and BFV signature mutations. Analysis of 186 RRV and 88 BFV genomes demonstrated their viral evolution trajectories have involved repeated selection of mutations, particularly in the nonstructural protein 1 (

Indexed as

AlphavirusBarmah Forest virusconvergent evolutiondiscrete-trait analysisRoss River virusTogaviridae

Identifiers

PMID39411152
PMCPMC11477980

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.