Evidence map›Paper›PMID 39410996›Full record

ReviewFrontiers in neurology2024

The neural substrates of bruxism: current knowledge and clinical implications.

Karin Harumi Uchima Koecklin, Aron Aliaga-Del Castillo, Peng Li

Registry-linked trialAbstract readReview
In one paragraph

Review in Frontiers in neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07336082 (Somatosensory Training Versus Exercise Therapy in Awake Bruxism), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07336082 narecruitingnot on this mapstarted 2025, after this paper: background citation

Somatosensory Training Versus Exercise Therapy in Awake Bruxism: A Randomized Controlled Trial

TypeinterventionalSponsorAydin Adnan Menderes UniversityRan2025 to 2026Enrolled20ConditionsBruxismArmsJaw exercise therapy, Somatosensory Awareness-Based Training, Wait-List Control
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Mechanical control in dental and jaw morphogenesis and remodeling.International journal of oral science · 2026
    Review
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  16. Prevalence of Bruxism and Its Association With Sleep Disturbances, Anxiety, and Oral Health-Related Quality of Life in Children With Autism Spectrum Disorder.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Karin Harumi Uchima KoecklinLife Sciences Institute, University of Michigan, Ann Arbor, MI, United States.
Aron Aliaga-Del CastilloDepartment of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, MI, United States.
Peng LiLife Sciences Institute, University of Michigan, Ann Arbor, MI, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bruxism is a complex orofacial behavior that can occur during sleep or wakefulness, characterized by the involuntary grinding or clenching of teeth, involving repetitive activity of the jaw muscles. Its etiology is multifactorial, influenced by genetic, psychological, physiological, and lifestyle factors. While the mild bruxism may not necessitate treatment, severe bruxism can lead to significant consequences, including tooth damage, jaw pain, fatigue, and headaches. The bruxism has been associated with medical conditions, such as stress, anxiety, sleep disorders, and various neurological disorders; however, the exact pathophysiology remains elusive. Although the central nervous system is strongly implicated in the development of bruxism, specific neural substrates have not yet been conclusively established. Furthermore, there is evidence to suggest that individuals with bruxism may exhibit neural plasticity, resulting in the establishment of distinct neural circuitry that control the jaw movements. The application of various neurophysiological techniques in both clinical and pre-clinical studies provides valuable insights into the neural mechanisms underlying bruxism. This review aims to comprehensively examine the current literature on the neural pathways involved in bruxism, with the goal of improving the clinical approach and therapeutics for this condition. A deeper understanding of the neural circuitry controlling bruxism holds the potential to advance future treatment approaches and improve the management of patients with bruxism.

Indexed as

brainbruxismjaw musclesneural substratesneuroimagingorofacial behaviortrigeminal

Identifiers

PMID39410996
PMCPMC11473305

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.