Evidence map›Paper›PMID 39410965›Full record

ArticlemicroPublication biology2024

A viable hypomorphic mutation in the mitochondrial ribosome subunit, MRPS-31, exhibits mitochondrial dysfunction in

Kylie M Jozwik, James P Held, Chloe A Hecht, Maulik R Patel

Abstract read
In one paragraph

Article in microPublication biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kylie M JozwikDepartment of Biological Sciences, Vanderbilt University, Nashville, Tennessee, United States.
James P HeldDepartment of Biological Sciences, Vanderbilt University, Nashville, Tennessee, United States.
Chloe A HechtDepartment of Biological Sciences, Vanderbilt University, Nashville, Tennessee, United States.
Maulik R PatelDepartment of Biological Sciences, Vanderbilt University, Nashville, Tennessee, United States.

Funding

TRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGYT32ES007028 · NIEHS · VANDERBILT UNIVERSITY · PI F PETER Guengerich, Fiona Edith Harrison · 1985 to 2026
$15.7M
Mechanisms of mutant mitochondrial genome modulationR35GM145378 · NIGMS · VANDERBILT UNIVERSITY · PI MAULIK R PATEL · 2022 to 2026
$2.4M
NIEHS NIH HHS T32 ES007028NIGMS NIH HHS R35 GM145378
6 · The paper itself

Abstract

The mitochondrial ribosome (mitoribosome) translates mitochondrial genome encoded proteins essential for cellular energy production. Given this critical role, defects in the mitoribosome can cause mitochondrial stress and manifest as multisystemic diseases. In a screen for unique activators of the mitochondrial unfolded protein response (UPR

Identifiers

PMID39410965
PMCPMC11474418

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.