Evidence map›Paper›PMID 39410888›Full record

ReviewCurrent topics in medicinal chemistry2025

Non-fused Pyrimidine Derivatives as Potential Pharmacological Entities: A Review.

Khyati L Bharti, Parnas S Parmar, Bhavesh P Rathod, Sharmil N Anjirwala, Saurabh K Patel

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current topics in medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Khyati L BhartiDepartment of Chemistry, Veer Narmad South Gujarat University, Surat-395007, Gujarat, India.
Parnas S ParmarDepartment of Chemistry, Veer Narmad South Gujarat University, Surat-395007, Gujarat, India.
Bhavesh P RathodDepartment of Chemistry, Veer Narmad South Gujarat University, Surat-395007, Gujarat, India.
Sharmil N AnjirwalaDepartment of Chemistry, Veer Narmad South Gujarat University, Surat-395007, Gujarat, India.
Saurabh K PatelDepartment of Chemistry, Veer Narmad South Gujarat University, Surat-395007, Gujarat, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-fused pyrimidine scaffold is a significant component for designing new drugs. The review emphasizes the pharmacological importance of non-fused pyrimidine-containing moieties based on the broad spectrum of activities such as antiprotozoal, antibacterial, antimycobacterial, anticancer, anti-inflammatory activity, and CNS depressant. Pyrimidine derivatives are fascinating entities that display biological activities for the treatment of cancer. It also highlights the tendency of non-fused pyrimidine derivatives to suppress cell growth by obstructing the activity of VCP, CDK-2, EGFR, ATR, EphB4 & EphA2, PDGF as well as inhibitory action towards different cell lines such as MCF-7, HeLa, NCI/ADR-RES, NCIH23, HOP-92, HCT-116, OV-3, MOLT-4, PC-3, MDA-MB-231, MALME-3M, K562 and Bcr-Abl. The review details the importance of morpholine, piperidine, and pyrrolidine ring substitutions on pyrimidine moiety as well as the role of H-bonding and amino linkage along with antibacterial activity due to the presence of pleuromutilin and tetrazole molecules. Researchers were motivated to develop and enhance the non-fused pyrimidine scaffold to uncover novel medicines by reading this review article.

Indexed as

Anti-Bacterial AgentsAntineoplastic AgentsPyrimidinesAnti-Inflammatory AgentsAntimalarialsCell Line, TumorDrug DesignHumansMolecular StructureAnti-Bacterial AgentsAnti-Inflammatory AgentsAntimalarialsAntineoplastic AgentsPyrimidinesAnti-bacteriaAnti-proliferativeAntiprotozoalCancer InhibitorsCytotoxicity.Non-fused pyrimidines

Identifiers

PMID39410888

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.