Evidence map›Paper›PMID 39410706›Full record

ArticleObesity (Silver Spring, Md.)2024

Gastric bypass elicits persistent gut adaptation and unique diabetes remission-related metabolic gene regulation.

Margaret A Stefater-Richards, Courtney Panciotti, Valerie Esteva, Miriam Lerner, Carter R Petty, William F Gourash, Anita P Courcoulas

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02710370 (Intestinal Metabolic Reprogramming as a Key Mechanism of Gastric Bypass in Humans), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02710370 active not recruitingnot on this map

Intestinal Metabolic Reprogramming as a Key Mechanism of Gastric Bypass in Humans

TypeobservationalSponsorUniversity of PittsburghRan2016 to 2028Enrolled46ConditionsObesity, Diabetes Mellitus, Type 2, Endocrine System Diseases, Glucose Metabolism Disorders
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Margaret A Stefater-RichardsDivision of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-4767-868X
Courtney PanciottiDivision of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA.
Valerie EstevaDivision of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA.
Miriam LernerDivision of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA.
Carter R PettyBiostatistics and Research Design Center, Boston Children's Hospital, Boston, Massachusetts, USA.
William F GourashDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Anita P CourcoulasDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Funding

Intestinal Metabolic Reprogramming as a Key Mechanism of Gastric Bypass in HumansR01DK108642 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI STYLOPOULOS, NICHOLAS · 2015 to 2019
$2.2M
Role of intestinal luminal and epigenetic factors to mediate intestinal metabolic remodeling after gastric bypass surgery - Administrative SupplementK08DK125878 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI STEFATER-RICHARDS, MARGARET · 2020 to 2023
$757k
Intestinal Mechanisms and Molecular Predictors of Type 2 Diabetes Remission After Roux-en-Y Gastric Bypass SurgeryR56DK125816 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI STYLOPOULOS, NICHOLAS · 2020 to 2020
$160k
NIDDK NIH HHS K08 DK125878NIDDK NIH HHS K08DK125878NIDDK NIH HHS R01 DK108642NIDDK NIH HHS R01DK108642NIDDK NIH HHS R56 DK125816NIDDK NIH HHS R56DK125816
6 · The paper itself

Abstract

objectiveWe have previously shown that early intestinal adaptation precedes and relates to metabolic improvement in humans after Roux-en-Y gastric bypass surgery (RYGB). We hypothesized that intestinal adaptation would persist at the 1-year postoperative time point and that gene expression (GE) signatures would relate to type 2 diabetes remission, providing insight into potential mechanisms for intestinally mediated metabolic improvement after RYGB.

methodsWe determined GE by RNA sequencing in jejunum (Roux limb [RL]) collected from 28 patients before and 12 months after RYGB.

resultsGlobal GE from paired baseline and 1-year jejunal samples did not separate according to clinical phenotype (type 2 diabetes remission, sustained weight loss). In general, GE was consistent with persistent RL remodeling, and microvilli were elongated by 39%. Remodeling was not attenuated in patients with lack of diabetes remission or with weight regain. Patients with diabetes remission demonstrated greater jejunal activation of lipogenesis-related pathways driven by RXR, LXR, and SREBP.

conclusionsRL adaptation is a key feature of RYGB in all patients, likely reflecting the dramatic alterations to gastrointestinal anatomy, but jejunal lipogenesis appears to be more strongly activated in those patients with diabetes remission. Further study is needed to understand whether these pathways may drive metabolic remission after RYGB.

Indexed as

Adaptation, PhysiologicalDiabetes Mellitus, Type 2Gastric BypassJejunumRemission InductionAdultFemaleGene Expression RegulationHumansLipogenesisMaleMiddle AgedObesity, MorbidWeight Loss

Identifiers

PMID39410706
PMCPMC11537825

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.