Evidence map›Paper›PMID 39410582›Full record

ArticleDiagnostics (Basel, Switzerland)2024

Performance of Elecsys

Prooksa Ananchuensook, Jongkonnee Wongpiyabovorn, Anchalee Avihingsanon, Pisit Tangkijvanich

Abstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Prooksa AnanchuensookDivision of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0000-0001-7513-7245
Jongkonnee WongpiyabovornDepartment of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Anchalee AvihingsanonThe HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), Bangkok 10330, Thailand.ORCID 0000-0003-3222-9611
Pisit TangkijvanichCenter of Excellence in Hepatitis and Liver Cancer, Department of Biochemistry, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0000-0002-2926-8671

Funding

This research received funding support from the NSRF via the Program Management Unit for Human Resources & Institutional Development, Research and Innovation (PMU-B), Center of Excellence in Hepatitis and Liver Cancer, Chulalongkorn University. and Roche B38G670012
6 · The paper itself

Abstract

BACKGROUND/

objectivesThe Elecsys

methodsBlood samples from 100 healthy controls, as well as 64 HCV mono-infection and 136 HCV-HIV coinfections, were collected before and 12-24 weeks after DAAs. The assay performance for determining active infection at baseline and SVR was compared with HCV RNA.

resultsOverall, 156 (78.0%) of HCV-infected patients had HCV genotype 1, and the SVR rate was 96.5%. The sensitivity, specificity, and area under the ROC curve (AUROC) for HCV diagnosis at baseline were 99.50% (95% confidence interval [CI], 96.82-99.97%), 100% (95%CI, 95.39-100%), and 0.998 (95%CI, 0.992-1.003), respectively. The corresponding results for HCV-Ag in determining SVR were 57.14% (95%CI, 20.24-88.19%), 97.41% (95%CI, 93.73-99.04%), and 0.773 (95%CI, 0.543-1.003), respectively. The assay also exhibited comparable sensitivity and specificity between HCV mono- and coinfection.

conclusionsOur study showed that the Elecsys

Indexed as

chronic hepatitis C virus (HCV) infectiondirect-acting antivirals (DAAs)Elecsys® HCV Duo immunoassayHCV antibodiesHCV core antigensustainedvirological response (SVR)

Identifiers

PMID39410582
PMCPMC11475452

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.