Evidence map›Paper›PMID 39410534›Full record

ArticleDiagnostics (Basel, Switzerland)2024

Evaluation of Diagnostic Performance of Three Commercial Interferon-Gamma Release Assays for

Richard Kutame, Gifty Boateng, Yaw Adusi-Poku, Felix Sorvor, Lorreta Antwi, Florence Agyemang-Bioh, Bright Ayensu, Vincent Gyau-Boateng, Franklin Asiedu-Bekoe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Diagnostic Performance of New Commercial Interferon-Gamma Release Assays for Mycobacterium tuberculosis Infection: An Updated Systematic Review and Meta-analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Pooled it
  2. Pooled it
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Richard KutameNational Public Health and Reference Laboratory, Harley Street, Korle Bu Teaching Hospital, Accra P.O. Box GP300, Ghana.
Gifty BoatengNational Public Health and Reference Laboratory, Harley Street, Korle Bu Teaching Hospital, Accra P.O. Box GP300, Ghana.ORCID 0000-0002-8833-7235
Yaw Adusi-PokuNational TB Control Programme, Korle Bu Teaching Hospital, Accra P.O. Box KB493, Ghana.
Felix SorvorNational TB Control Programme, Korle Bu Teaching Hospital, Accra P.O. Box KB493, Ghana.
Lorreta AntwiNational Public Health and Reference Laboratory, Harley Street, Korle Bu Teaching Hospital, Accra P.O. Box GP300, Ghana.
Florence Agyemang-BiohNational Public Health and Reference Laboratory, Harley Street, Korle Bu Teaching Hospital, Accra P.O. Box GP300, Ghana.ORCID 0000-0001-9031-8925
Bright AyensuNational Public Health and Reference Laboratory, Harley Street, Korle Bu Teaching Hospital, Accra P.O. Box GP300, Ghana.
Vincent Gyau-BoatengNational Public Health and Reference Laboratory, Harley Street, Korle Bu Teaching Hospital, Accra P.O. Box GP300, Ghana.
Franklin Asiedu-BekoePublic Health Division, Ghana Health Service, Korle Bu Teaching Hospital, P.M.B. Ministries, Accra P.O. Box MB582, Ghana.

Funding

SD Biosensor N/A
6 · The paper itself

Abstract

Interferon-gamma release assays (IGRAs) have gained attention for the diagnosis of latent tuberculosis infection (LTBI) due to their higher specificity compared to the tuberculin skin test (TST). However, the IGRA's performance varies across different populations. This study evaluated the diagnostic performance of three IGRAs (TBF-FIA, TBF-ELISA, and QFT-Plus) in Ghana, comparing them among individuals exposed and unexposed to MTB infection. Conducted in TB clinics across three regions, this prospective and cross-sectional study included healthy individuals with no known TB exposure (unexposed group) and patients with confirmed active TB (exposed group). Blood samples were tested using all three assays as per the manufacturers' guidelines. The TBF-ELISA showed 3.4% higher sensitivity but 4.6% lower specificity compared to QFT-Plus. The TBF-FIA had sensitivity of 78.5-87.3% and specificity of 82.9-90.0%. These findings indicate that while the three IGRAs offer similar diagnostic accuracy, the variations in specificity and limited data on assays like TBF-FIA require further investigation.

Indexed as

diagnosisevaluationIGRAinterferon gammaMycobacterium tuberculosisSD biosensortuberculosis

Identifiers

PMID39410534
PMCPMC11475782

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.