Evidence map›Paper›PMID 39409927›Full record

ArticleCancers2024

First-Line Use of Daratumumab in Patients with Multiple Myeloma Shows Delayed Neutrophil and Platelet Engraftment after Autologous Stem Cell Transplantation: Results from a Real-Life Single-Center Study.

Massimo Martino, Mercedes Gori, Gaetana Porto, Giorgia Policastro, Martina Pitea, Annalisa Sgarlata, Ilaria Maria Delfino, Francesca Cogliandro, Anna Scopelliti, Giovanna Utano and 12 more

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Massimo MartinoHematology and Stem Cell Transplantation and Cellular Therapies Unit (CTMO), Department of Hemato-Oncology and Radiotherapy, Grande OspedaleMetropolitano"Bianchi-Melacrino-Morelli", 89133 Reggio Calabria, Italy.ORCID 0000-0002-3987-419X
Mercedes GoriInstitute of Clinical Physiology (IFC-CNR), Section of Rome, 00185 Rome, Italy.ORCID 0000-0003-0081-3549
Gaetana PortoHematology and Stem Cell Transplantation and Cellular Therapies Unit (CTMO), Department of Hemato-Oncology and Radiotherapy, Grande OspedaleMetropolitano"Bianchi-Melacrino-Morelli", 89133 Reggio Calabria, Italy.
Giorgia PolicastroHematology and Stem Cell Transplantation and Cellular Therapies Unit (CTMO), Department of Hemato-Oncology and Radiotherapy, Grande OspedaleMetropolitano"Bianchi-Melacrino-Morelli", 89133 Reggio Calabria, Italy.
Martina PiteaHematology and Stem Cell Transplantation and Cellular Therapies Unit (CTMO), Department of Hemato-Oncology and Radiotherapy, Grande OspedaleMetropolitano"Bianchi-Melacrino-Morelli", 89133 Reggio Calabria, Italy.ORCID 0000-0002-3982-4141
Annalisa SgarlataHematology and Stem Cell Transplantation and Cellular Therapies Unit (CTMO), Department of Hemato-Oncology and Radiotherapy, Grande OspedaleMetropolitano"Bianchi-Melacrino-Morelli", 89133 Reggio Calabria, Italy.
Ilaria Maria DelfinoHematology and Stem Cell Transplantation and Cellular Therapies Unit (CTMO), Department of Hemato-Oncology and Radiotherapy, Grande OspedaleMetropolitano"Bianchi-Melacrino-Morelli", 89133 Reggio Calabria, Italy.ORCID 0000-0002-1597-1913
Francesca CogliandroHematology and Stem Cell Transplantation and Cellular Therapies Unit (CTMO), Department of Hemato-Oncology and Radiotherapy, Grande OspedaleMetropolitano"Bianchi-Melacrino-Morelli", 89133 Reggio Calabria, Italy.
Anna ScopellitiStem Cell Transplant Program CIC587, 89124 Reggio Calabria, Italy.
Giovanna UtanoHematology and Stem Cell Transplantation and Cellular Therapies Unit (CTMO), Department of Hemato-Oncology and Radiotherapy, Grande OspedaleMetropolitano"Bianchi-Melacrino-Morelli", 89133 Reggio Calabria, Italy.
Maria PellicanoStem Cell Transplant Program CIC587, 89124 Reggio Calabria, Italy.
Aurora IdatoHematology and Stem Cell Transplantation and Cellular Therapies Unit (CTMO), Department of Hemato-Oncology and Radiotherapy, Grande OspedaleMetropolitano"Bianchi-Melacrino-Morelli", 89133 Reggio Calabria, Italy.
Iolanda Donatella VincelliHematology and Stem Cell Transplantation and Cellular Therapies Unit (CTMO), Department of Hemato-Oncology and Radiotherapy, Grande OspedaleMetropolitano"Bianchi-Melacrino-Morelli", 89133 Reggio Calabria, Italy.
Violetta MarafiotiHematology and Stem Cell Transplantation and Cellular Therapies Unit (CTMO), Department of Hemato-Oncology and Radiotherapy, Grande OspedaleMetropolitano"Bianchi-Melacrino-Morelli", 89133 Reggio Calabria, Italy.
Maria Caterina MicòHematology and Stem Cell Transplantation and Cellular Therapies Unit (CTMO), Department of Hemato-Oncology and Radiotherapy, Grande OspedaleMetropolitano"Bianchi-Melacrino-Morelli", 89133 Reggio Calabria, Italy.
Giuseppe LazzaroHematology and Stem Cell Transplantation and Cellular Therapies Unit (CTMO), Department of Hemato-Oncology and Radiotherapy, Grande OspedaleMetropolitano"Bianchi-Melacrino-Morelli", 89133 Reggio Calabria, Italy.
Barbara LotetaHematology and Stem Cell Transplantation and Cellular Therapies Unit (CTMO), Department of Hemato-Oncology and Radiotherapy, Grande OspedaleMetropolitano"Bianchi-Melacrino-Morelli", 89133 Reggio Calabria, Italy.
Caterina AlatiHematology and Stem Cell Transplantation and Cellular Therapies Unit (CTMO), Department of Hemato-Oncology and Radiotherapy, Grande OspedaleMetropolitano"Bianchi-Melacrino-Morelli", 89133 Reggio Calabria, Italy.
Giovanni LeanzaPharmacy Unit, Grande Ospedale Metropolitano "Bianchi-Melacrino-Morelli", 89133 Reggio Calabria, Italy.
Graziella D'ArrigoInstitute of Clinical Physiology (IFC-CNR), Section of Reggio Calabria, 89124 Reggio Calabria, Italy.
Giovanni Luigi TripepiInstitute of Clinical Physiology (IFC-CNR), Section of Reggio Calabria, 89124 Reggio Calabria, Italy.
Annalisa PitinoInstitute of Clinical Physiology (IFC-CNR), Section of Rome, 00185 Rome, Italy.ORCID 0000-0002-7768-3925

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis real-life study aimed to investigate the possible impact of D-VTd induction therapy on hematopoietic engraftment after autologous stem cell transplantation (auto-SCT).

methodsSixty consecutive NDMM patients received four cycles of induction therapy with D-VTd. The conditioning regimen consisted of melphalan 200 mg/m

resultsThe median days to reach neutrophil and platelet engraftment significantly differed between patients treated with D-VTd (11 and 13 days, respectively) and VTd (10 and 12 days). Univariate Cox analyses show that patients treated with D-VTd had a hazard ratio of neutrophil engraftment that was 42% significantly lower than those in the VTd arm (HR: 0.58,

conclusionsOur real-life study showed that a four-drug induction therapy containing DARA does not impact transplant safety outcomes.

Indexed as

autologous stem cell transplantationdaratumumabmultiple myelomaneutrophil and platelet engraftment

Identifiers

PMID39409927
PMCPMC11475878

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.