Evidence map›Paper›PMID 39409322›Full record

ArticleSensors (Basel, Switzerland)2024

Early Diagnosis of Bronchopulmonary Dysplasia with E-Nose: A Pilot Study in Preterm Infants.

Laura Tenero, Michele Piazza, Marco Sandri, Giuliana Ferrante, Elisabetta Giacomello, Benjamim Ficial, Marco Zaffanello, Paolo Biban, Giorgio Piacentini

Abstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Laura TeneroPediatric Section, Azienda Ospedaliera Universitaria Integrata Verona, 37126 Verona, Italy.ORCID 0000-0002-4738-8319
Michele PiazzaDepartment of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, 37129 Verona, Italy.ORCID 0000-0001-7746-8267
Marco SandriDepartment of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, 37129 Verona, Italy.ORCID 0000-0002-1422-5695
Giuliana FerranteDepartment of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, 37129 Verona, Italy.ORCID 0000-0001-9917-2387
Elisabetta GiacomelloDepartment of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, 37129 Verona, Italy.
Benjamim FicialNeonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Integrata Verona, 37126 Verona, Italy.ORCID 0000-0001-6056-5757
Marco ZaffanelloDepartment of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, 37129 Verona, Italy.ORCID 0000-0002-8659-5505
Paolo BibanNeonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Integrata Verona, 37126 Verona, Italy.ORCID 0000-0001-7073-6265
Giorgio PiacentiniDepartment of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, 37129 Verona, Italy.ORCID 0000-0003-1324-4373

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bronchopulmonary dysplasia (BPD) is the most common respiratory disease in preterm and is still associated with increased mortality and morbidity. The great interest lies in identifying early biomarkers that can predict the development of BPD. This pilot study explores the potential of e-nose for the early identification of BPD risk in premature infants by analyzing volatile organic compounds (VOCs) in the exhaled breath condensate (EBC). Fourteen mechanically ventilated very preterm infants were included in this study. The clinical parameters and EBC were collected within the first 24 h of life. The discriminative ability of breath prints between preterms who did and did not develop BPD was investigated using pattern recognition, a machine learning algorithm, and standard statistical methods. We found that e-nose probes can significantly predict the outcome of "no-BPD" vs. "BPD". Specifically, a subset of probes (S18, S24, S14, and S6) were found to be significantly predictive, with an AUC of 0.87, 0.89, 0.82, 0.8, and

Indexed as

Breath TestsBronchopulmonary DysplasiaEarly DiagnosisElectronic NoseInfant, PrematureVolatile Organic CompoundsAlgorithmsBiomarkersFemaleHumansInfant, NewbornMachine LearningMalePilot ProjectsBiomarkersVolatile Organic Compoundsbreathomicsbronchopulmonary dysplasiaelectronic nosemechanical ventilationpretermsvolatile organic compounds

Identifiers

PMID39409322
PMCPMC11479126

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.