Evidence map›Paper›PMID 39409108›Full record

ArticleInternational journal of molecular sciences2024

Unveiling the Anticancer Potential: Computational Exploration of Nitrogenated Derivatives of (+)-Pancratistatin as Topoisomerase I Inhibitors.

Magdi Awadalla Mohamed, Tilal Elsaman, Abozer Y Elderdery, Abdullah Alsrhani, Heba Bassiony Ghanem, Majed Mowanes Alruwaili, Siddiqa M A Hamza, Salma Elhadi Ibrahim Mekki, Hazim Abdullah Alotaibi, Jeremy Mills

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Magdi Awadalla MohamedDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka 72388, Saudi Arabia.ORCID 0000-0003-1981-6408
Tilal ElsamanDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka 72388, Saudi Arabia.ORCID 0000-0003-3875-7968
Abozer Y ElderderyDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 42421, Saudi Arabia.ORCID 0000-0002-6219-5312
Abdullah AlsrhaniDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 42421, Saudi Arabia.ORCID 0000-0002-6839-8866
Heba Bassiony GhanemDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 42421, Saudi Arabia.
Majed Mowanes AlruwailiNursing Administration & Education Department, College of Nursing, Jouf University, Sakaka 72388, Saudi Arabia.ORCID 0000-0001-8491-8190
Siddiqa M A HamzaDepartment of Pathology, College of Medicine, Umm Alqura University, Algunfudah 21912, Saudi Arabia.
Salma Elhadi Ibrahim MekkiDeparment of Physiology, College of Medicine, Umm Alqura University, Alqunfudah 21912, Saudi Arabia.
Hazim Abdullah AlotaibiDepartment of Medical Oncology, Prince Mohammad Medical City, Aljouf 11443, Saudi Arabia.
Jeremy MillsSchool of Medicine, Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, UK.ORCID 0000-0003-1719-9047

Funding

The Deanship of Graduate Studies and Scientific Research at Jouf University DGSSR-2024-01-01003
6 · The paper itself

Abstract

Cancer poses a substantial global health challenge, driving the need for innovative therapeutic solutions that offer improved effectiveness and fewer side effects. Topoisomerase I (Topo I) has emerged as a validated molecular target in the pursuit of developing anticancer drugs due to its critical role in DNA replication and transcription. (+)-Pancratistatin (PST), a naturally occurring compound found in various

Indexed as

Amaryllidaceae AlkaloidsAntineoplastic AgentsDNA Topoisomerases, Type IIsoquinolinesMolecular Docking SimulationMolecular Dynamics SimulationTopoisomerase I InhibitorsHumansProtein BindingAmaryllidaceae AlkaloidsAntineoplastic AgentsDNA Topoisomerases, Type IIsoquinolinespancratistatinTopoisomerase I InhibitorsAmaryllidaceae alkaloidsCADDcancer(+)-PancratistatinTopoisomerase I

Identifiers

PMID39409108
PMCPMC11476810

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.