Evidence map›Paper›PMID 39409096›Full record

ArticleInternational journal of molecular sciences2024

3',4'-Dihydroxyflavonol Inhibits Fibrotic Response in a Rabbit Model of Glaucoma Filtration Surgery.

Zoe Pasvanis, Roy C K Kong, Manisha H Shah, Elsa C Chan, Jennifer C Fan Gaskin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zoe PasvanisOphthalmology, Department of Surgery, University of Melbourne, Fitzroy, VIC 3065, Australia.ORCID 0000-0002-1162-5378
Roy C K KongOphthalmology, Department of Surgery, University of Melbourne, Fitzroy, VIC 3065, Australia.
Manisha H ShahOphthalmology, Department of Surgery, University of Melbourne, Fitzroy, VIC 3065, Australia.
Elsa C ChanOphthalmology, Department of Surgery, University of Melbourne, Fitzroy, VIC 3065, Australia.ORCID 0000-0002-6604-5426
Jennifer C Fan GaskinOphthalmology, Department of Surgery, University of Melbourne, Fitzroy, VIC 3065, Australia.

Funding

Australian Vision Research AVR grant 2022
6 · The paper itself

Abstract

Post-operative fibrosis of the filtering bleb limits the success of glaucoma filtration surgery (GFS). To minimise subconjunctival scarring following GFS, treatment with antimetabolites such as Mitomycin C (MMC) has become standard practice; however, their use is associated with considerable side effects. This study aimed to investigate the anti-scarring properties of 3',4'-dihydroxyflavonol (DiOHF). GFS was performed in New Zealand white rabbits who received eye drops of DiOHF three times daily and vehicle eye drops after surgery (

Indexed as

Disease Models, AnimalFibrosisFiltering SurgeryFlavonolsGlaucomaAnimalsCollagenConjunctivaMitomycinOxidative StressRabbits3',4'-dihydroxyflavonolCollagenFlavonolsMitomycinantifibroticconjunctival scarringglaucoma filtration surgery

Identifiers

PMID39409096
PMCPMC11476621

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.