Evidence map›Paper›PMID 39409080›Full record

ArticleInternational journal of molecular sciences2024

Plasma Proteomic Biomarkers in Alzheimer's Disease and Cardiovascular Disease: A Longitudinal Study.

Laurie A Theeke, Ying Liu, Silas Wang, Xingguang Luo, R Osvaldo Navia, Danqing Xiao, Chun Xu, Kesheng Wang, The Alzheimer And Disease Neuroimaging Initiative

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Laurie A TheekeDepartment of Community of Acute and Chronic Care, School of Nursing, The George Washington University, Ashburn, VA 20147, USA.ORCID 0000-0002-6965-0728
Ying LiuDepartment of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, TN 37614, USA.
Silas WangDepartment of Statistics & Data Science, Dietrich College of Humanities and Social Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Xingguang LuoDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA.ORCID 0000-0003-3585-042X
R Osvaldo NaviaDepartment of Medicine and Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, USA.
Danqing XiaoDepartment of STEM, School of Arts and Sciences, Regis College, Weston, MA 02493, USA.ORCID 0000-0002-6963-2933
Chun XuDepartment of Health and Biomedical Sciences, College of Health Affairs, University of Texas Rio Grande Valley, Brownsville, TX 78520, USA.ORCID 0000-0001-7893-6341
Kesheng WangDepartment of Biobehavioral Health & Nursing Science, College of Nursing, University of South Carolina, Columbia, 1601 Greene Street, Columbia, SC 29208, USA.ORCID 0000-0001-7118-3877
The Alzheimer And Disease Neuroimaging Initiative

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The co-occurrence of Alzheimer's disease (AD) and cardiovascular diseases (CVDs) in older adults highlights the necessity for the exploration of potential shared risk factors. A total of 566 adults were selected from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, including 111 individuals with AD, 383 with mild cognitive impairment (MCI), and 410 with CVD. The multivariable linear mixed model (LMM) was used to investigate the associations of AD and CVD with longitudinal changes in 146 plasma proteomic biomarkers (measured at baseline and the 12-month follow-up). The LMM showed that 48 biomarkers were linked to AD and 46 to CVD (

Indexed as

Alzheimer DiseaseBiomarkersCardiovascular DiseasesCognitive DysfunctionProteomicsAgedAged, 80 and overFemaleHumansLongitudinal StudiesMaleBiomarkersAlzheimer’s diseaseAPOE-ε4biomarkerscardiovascular diseaseslinear mixed modelmild cognitive impairmentproteomics

Identifiers

PMID39409080
PMCPMC11477191

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.