Evidence map›Paper›PMID 39409044›Full record

ArticleInternational journal of molecular sciences2024

Pig Milk Exosome Packaging ssc-miR-22-3p Alleviates Pig Intestinal Epithelial Cell Injury and Inflammatory Response by Targeting

Jie Li, Huihui Hu, Panpan Fu, Qiaoli Yang, Pengfei Wang, Xiaoli Gao, Jiaojiao Yang, Shuangbao Gun, Xiaoyu Huang

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The miR-214-3p/Biology · 2026
    Article
  2. Milk-Derived Extracellular Vesicles and microRNAs: Potential Modulators of Intestinal Homeostasis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jie LiCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
Huihui HuCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
Panpan FuCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
Qiaoli YangCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
Pengfei WangCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
Xiaoli GaoCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
Jiaojiao YangCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
Shuangbao GunCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
Xiaoyu HuangCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.

Funding

Animal Husbandry Pig Industry Technology Innovation Team Project of Gansu Agricultural University GAU-XKTD-2022-25National Natural Science Foundation of China 31960646National Natural Science Foundation of China 32360819Natural Science Foundation of Gansu Province 22JR5RA874Protection and Quality Improvement of Gansu Local Pig Germplasm Resources GSLK-2021-13
6 · The paper itself

Abstract

Inflammatory diseases of the intestinal tract in piglets severely impair the economic performance of pig farms. Pig milk exosomes can encapsulate miRNAs which can then enter the piglet intestine to play an immunomodulatory role. Previously, we comparatively analyzed and identified exosomal miRNAs in the colostrum and mature milk of Bamei and Landrace pigs, and we screened for ssc-miR-22-3p, which is associated with inflammation and immune response; however, the role played by ssc-miR-22-3p in the immune response in IPEC-J2 cells is not yet clear. In this study, we first constructed a pig intestinal inflammatory response model using Lipopolysaccharide (LPS) and Polyinosinic-polycytidylic acid (Poly (I:C)), and we investigated the role of ssc-miR-22-3p targeting

Indexed as

Epithelial CellsExosomesInflammationLipopolysaccharidesMicroRNAsAnimalsCell LineIntestinal MucosaMilkPoly I-CSwineLipopolysaccharidesMicroRNAsPoly I-Ccell viability and proliferationintestinal inflammatory injurypig milk exosomesssc-miR-22-3p

Identifiers

PMID39409044
PMCPMC11476862

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.