Evidence map›Paper›PMID 39409033›Full record

ReviewInternational journal of molecular sciences2024

A Brief Overview of Cholinergic and Phosphodiesterase-5 Inhibitors in Diabetic Bladder Dysfunction.

Georgios Kallinikas, Georgios Haronis, Eirini Kallinika, Diomidis Kozyrakis, Evangelos Rodinos, Athanasios Filios, Panagiotis Filios, Despoina Mityliniou, Konstantinos Safioleas, Anastasios Zarkadas and 6 more

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Georgios KallinikasDepartment of Urology, Konstantopouleion-Patision Hospital, N. Ionia, 14233 Attika, Greece.
Georgios HaronisDepartment of Urology, Konstantopouleion-Patision Hospital, N. Ionia, 14233 Attika, Greece.ORCID 0009-0005-2874-8824
Eirini KallinikaDepartment of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Diomidis KozyrakisDepartment of Urology, Konstantopouleion-Patision Hospital, N. Ionia, 14233 Attika, Greece.ORCID 0000-0003-1236-4381
Evangelos RodinosDepartment of Urology, Konstantopouleion-Patision Hospital, N. Ionia, 14233 Attika, Greece.
Athanasios FiliosDepartment of Urology, Konstantopouleion-Patision Hospital, N. Ionia, 14233 Attika, Greece.
Panagiotis FiliosDepartment of Urology, Konstantopouleion-Patision Hospital, N. Ionia, 14233 Attika, Greece.
Despoina MityliniouDepartment of Urology, Konstantopouleion-Patision Hospital, N. Ionia, 14233 Attika, Greece.
Konstantinos SafioleasDepartment of Urology, Konstantopouleion-Patision Hospital, N. Ionia, 14233 Attika, Greece.
Anastasios ZarkadasDepartment of Urology, Konstantopouleion-Patision Hospital, N. Ionia, 14233 Attika, Greece.
Dimitrios BoziosDepartment of Urology, Konstantopouleion-Patision Hospital, N. Ionia, 14233 Attika, Greece.
Athanasios KarmogiannisDepartment of Urology, Konstantopouleion-Patision Hospital, N. Ionia, 14233 Attika, Greece.
Vasileios KonstantinopoulosDepartment of Urology, Konstantopouleion-Patision Hospital, N. Ionia, 14233 Attika, Greece.
Anna Maria KonomiDepartment of Urology, Konstantopouleion-Patision Hospital, N. Ionia, 14233 Attika, Greece.
Amin M EktesabiKeenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada.ORCID 0000-0002-0089-6826
James N TsoporisKeenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic bladder dysfunction (DBD) comprises a wide spectrum of lower urinary tract symptoms that impact diabetic patients' lives, including urinary frequency, urgency, incontinence, and incomplete bladder emptying. To relieve symptoms, anticholinergics have been widely prescribed and are considered an effective treatment. There is increasing evidence that diabetic patients may benefit from the use of phosphodiesterase 5 (PDE5) inhibitors. This narrative review aims to provide a brief overview of the pathophysiology of DBD along with a focus on cholinergic and phosphodiesterase inhibitors as therapies that benefit DBD. An examination of the literature suggests compelling avenues of research and underscores critical gaps in understanding the mechanisms underlying DBD. New tools and models, especially rodent models, are required to further elucidate the mechanisms of action of current therapies in the treatment of DBS.

Indexed as

Diabetes ComplicationsPhosphodiesterase 5 InhibitorsAnimalsCholinergic AntagonistsHumansUrinary BladderUrinary Bladder DiseasesCholinergic AntagonistsPhosphodiesterase 5 Inhibitorsacetylcholineanti-cholinergic drugsdiabetic bladdermuscarinic receptorsPDE5PDE5 inhibitors

Identifiers

PMID39409033
PMCPMC11476953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.