Evidence map›Paper›PMID 39409020›Full record

ArticleInternational journal of molecular sciences2024

Molecular Mechanism of 5,6-Dihydroxyflavone in Suppressing LPS-Induced Inflammation and Oxidative Stress.

Yujia Cao, Yee-Joo Tan, Dejian Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yujia CaoDepartment of Food Science and Technology, National University of Singapore, Singapore 117542, Singapore.ORCID 0000-0001-9984-3080
Yee-Joo TanInfectious Diseases Translational Research Program, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore.ORCID 0000-0002-2278-4497
Dejian HuangDepartment of Food Science and Technology, National University of Singapore, Singapore 117542, Singapore.ORCID 0000-0002-2305-3960

Funding

Singapore Ministry of Education A-8000983-01-00
6 · The paper itself

Abstract

5,6-dihydroxyflavone (5,6-DHF), a flavonoid that possesses potential anti-inflammatory and antioxidant activities owing to its special catechol motif on the A ring. However, its function and mechanism of action against inflammation and cellular oxidative stress have not been elucidated. In the current study, 5,6-DHF was observed inhibiting lipopolysaccharide (LPS)-induced nitric oxide (NO) and cytoplasmic reactive oxygen species (ROS) production with the IC

Indexed as

Anti-Inflammatory AgentsFlavonesInflammationLipopolysaccharidesOxidative StressReactive Oxygen SpeciesAnimalsFlavonoidsHeme Oxygenase-1Janus Kinase 2MacrophagesMiceNF-kappa BNitric OxideRAW 264.7 CellsSignal TransductionAnti-Inflammatory AgentsFlavonesFlavonoidsHeme Oxygenase-1Janus Kinase 2LipopolysaccharidesNF-kappa BNitric OxideReactive Oxygen SpeciesSTAT3 Transcription FactorToll-Like Receptor 45,6-dihydroxyflavoneanti-inflammationflavonoidsoxidative stresssignaling pathway

Identifiers

PMID39409020
PMCPMC11477439

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.