Epigenetic Reprogramming and Inheritance of the Cellular Differentiation Status Following Transient Expression of a Nonfunctional Dominant-Negative Retinoblastoma Mutant in Murine Mesenchymal Stem Cells.

Mikhail Baryshev, Irina Maksimova, Ilona Sasoveca

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mikhail BaryshevInstitute of Microbiology and Virology, Riga Stradins University, Ratsupites 5, LV-1067 Riga, Latvia.

Irina MaksimovaInstitute of Microbiology and Virology, Riga Stradins University, Ratsupites 5, LV-1067 Riga, Latvia.

Ilona SasovecaInstitute of Microbiology and Virology, Riga Stradins University, Ratsupites 5, LV-1067 Riga, Latvia.

Funding

Riga Stradins University No. 132311

6 · The paper itself

Abstract

The retinoblastoma gene product (Rb1), a master regulator of the cell cycle, plays a prominent role in cell differentiation. Previously, by analyzing the differentiation of cells transiently overexpressing the ΔS/N DN Rb1 mutant, we demonstrated that these cells fail to differentiate into mature adipocytes and that they constitutively silence

Indexed as

Cell DifferentiationDNA MethylationEpigenesis, GeneticMesenchymal Stem CellsAdipogenesisAnimalsCCAAT-Enhancer-Binding ProteinsCellular ReprogrammingDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3AEnhancer of Zeste Homolog 2 ProteinMiceMutationPPAR gammaPromoter Regions, GeneticRetinoblastoma ProteinCCAAT-Enhancer-Binding ProteinsCEBPA protein, mouseDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADnmt3a protein, mouseEnhancer of Zeste Homolog 2 ProteinEzh2 protein, mousePPAR gammaRetinoblastoma ProteinadipogenesisCebpaDNMTsepigenetic reprogrammingMSCsRb1

Identifiers

PMID39409007

DOI10.3390/ijms251910678

PMCPMC11476944

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.