Evidence map›Paper›PMID 39408999›Full record

ArticleInternational journal of molecular sciences2024

Exploring the Antibacterial and Antiparasitic Activity of Phenylaminonaphthoquinones-Green Synthesis, Biological Evaluation and Computational Study.

Sussan Lopez-Mercado, Cinthya Enríquez, Jaime A Valderrama, Ricardo Pino-Rios, Liliana Ruiz-Vásquez, Lastenia Ruiz Mesia, Gabriel Vargas-Arana, Pedro Buc Calderon, Julio Benites

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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  6. Reactions ofInternational journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sussan Lopez-MercadoMagister en Ciencias Químicas y Farmacéuticas, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile.
Cinthya EnríquezDoctorado en Química Medicinal, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile.ORCID 0000-0002-9839-7389
Jaime A ValderramaLaboratorio de Química Medicinal, Química y Farmacia, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile.
Ricardo Pino-RiosMagister en Ciencias Químicas y Farmacéuticas, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile.ORCID 0000-0003-4756-1115
Liliana Ruiz-VásquezCentro de Investigación de Recursos Naturales, Universidad Nacional de la Amazonía Peruana (UNAP), AA. HH. "Nuevo San Lorenzo", Pasaje Paujiles S/N, San Juan Bautista, Iquitos16002, Peru.ORCID 0000-0001-9042-7240
Lastenia Ruiz MesiaCentro de Investigación de Recursos Naturales, Universidad Nacional de la Amazonía Peruana (UNAP), AA. HH. "Nuevo San Lorenzo", Pasaje Paujiles S/N, San Juan Bautista, Iquitos16002, Peru.ORCID 0000-0002-9385-5416
Gabriel Vargas-AranaLaboratorio de Química de Productos Naturales, Instituto de Investigaciones de la Amazonía Peruana (IIAP), Av. Abelardo Quiñones km 2.5, Iquitos 16001, Peru.ORCID 0000-0002-0808-4283
Pedro Buc CalderonDoctorado en Química Medicinal, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile.
Julio BenitesMagister en Ciencias Químicas y Farmacéuticas, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile.ORCID 0000-0002-8562-0078

Funding

Fondo Interno VRII-UNAP, Chile VRIIP0056-21
6 · The paper itself

Abstract

Organic compounds with antibacterial and antiparasitic properties are gaining significance for biomedical applications. This study focuses on the solvent-free synthesis (green synthesis) of 1,4-naphthoquinone or 2,3-dichloro-1,4-naphthoquinone with different phenylamines using silica gel as an acid solid support. The study also includes in silico PASS predictions and the discovery of antibacterial and antiparasitic properties of phenylaminonaphthoquinone derivatives

Indexed as

Anti-Bacterial AgentsMicrobial Sensitivity TestsMolecular Docking SimulationNaphthoquinonesAntiparasitic AgentsGram-Negative BacteriaGreen Chemistry TechnologyPlasmodium falciparumAnti-Bacterial AgentsAntiparasitic AgentsNaphthoquinonesamination reactionantimicrobialantiplasmodialphenylaminonaphthoquinonessilica gelsolvent-free reaction

Identifiers

PMID39408999
PMCPMC11870044

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.