Evidence map›Paper›PMID 39408996›Full record

Observational studyInternational journal of molecular sciences2024

Histopathological and Immunohistochemical Characteristics of Different Types of Cardiac Amyloidosis.

Zarina V Gioeva, Liudmila M Mikhaleva, Nikita A Gutyrchik, Alexey V Volkov, Mikhail A Popov, Nikolay K Shakhpazyan, Valentina V Pechnikova, Konstantin Y Midiber, Elena V Reznik, Lev V Kakturskij

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zarina V GioevaAvtsyn Research Institute of Human Morphology, Petrovsky National Research Centre of Surgery, 117418 Moscow, Russia.ORCID 0000-0002-5456-8692
Liudmila M MikhalevaAvtsyn Research Institute of Human Morphology, Petrovsky National Research Centre of Surgery, 117418 Moscow, Russia.ORCID 0000-0003-2052-914X
Nikita A GutyrchikAvtsyn Research Institute of Human Morphology, Petrovsky National Research Centre of Surgery, 117418 Moscow, Russia.ORCID 0000-0002-2352-278X
Alexey V VolkovAvtsyn Research Institute of Human Morphology, Petrovsky National Research Centre of Surgery, 117418 Moscow, Russia.ORCID 0000-0002-5611-3990
Mikhail A PopovDepartment of Cardiac Surgery in M. F. Vladimirskiy Moscow Regional Research Clinical Institute, 129110 Moscow, Russia.ORCID 0000-0002-0316-8410
Nikolay K ShakhpazyanAvtsyn Research Institute of Human Morphology, Petrovsky National Research Centre of Surgery, 117418 Moscow, Russia.ORCID 0000-0003-3386-7746
Valentina V PechnikovaAvtsyn Research Institute of Human Morphology, Petrovsky National Research Centre of Surgery, 117418 Moscow, Russia.ORCID 0000-0001-5896-4556
Konstantin Y MidiberAvtsyn Research Institute of Human Morphology, Petrovsky National Research Centre of Surgery, 117418 Moscow, Russia.ORCID 0000-0002-1426-968X
Elena V ReznikDepartment of Internal Medicine №2, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.ORCID 0000-0001-7479-418X
Lev V KakturskijAvtsyn Research Institute of Human Morphology, Petrovsky National Research Centre of Surgery, 117418 Moscow, Russia.ORCID 0000-0001-7896-2080

Funding

Russian Science Foundation 23-15-00138
6 · The paper itself

Abstract

Cardiac involvement is the most important factor determining prognosis in patients with systemic amyloidosis. This retrospective observational study of 98 patients with amyloidosis was undertaken to assess the amyloid types that are most likely to affect the heart, describe histopathological and clinical features of cardiac amyloidosis, and estimate the number of cases not diagnosed clinically prior to death. All cases were divided into two groups based on the method of examination. The first group included 46 patients with cardiac amyloidosis revealed via endomyocardial biopsies (EMBs), and the second group included 52 amyloidosis patients who did not undergo EMBs, in whom cardiac involvement was identified only at autopsy. The EMBs demonstrated that AL amyloidosis was detected in 21 (46%) specimens, ATTR amyloid in 24 cases (52%), and AA amyloid in 1 case (2%). The autopsy reports defined 15 (46%) cases of AL amyloidosis, 21 (40%) of ATTR and 16 (31%) of AA amyloidosis. It should be noted that a clinical diagnosis of ATTR amyloidosis was made only in 9.5% of patients from the autopsy group, suggesting that ATTR may be an underdiagnosed cause of heart failure in elderly patients. The most intense amyloid deposits were determined in biopsy and autopsy specimens of patients with AL kappa amyloidosis, underlying a poorer prognosis.

Indexed as

AmyloidosisMyocardiumAdultAgedAged, 80 and overAmyloidAutopsyBiopsyCardiomyopathiesFemaleHumansImmunoglobulin Light-chain AmyloidosisImmunohistochemistryMaleMiddle AgedPrognosisAmyloidSerum Amyloid A Proteinamyloidcardiac amyloidosisendomyocardial biopsyimmunoglobulin light chainimmunohistochemistrytransthyretin

Identifiers

PMID39408996
PMCPMC11476653

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.