Evidence map›Paper›PMID 39408994›Full record

ReviewInternational journal of molecular sciences2024

Syntaxin 3B: A SNARE Protein Required for Vision.

Himani Dey, Mariajose Perez-Hurtado, Ruth Heidelberger

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Himani DeyDepartment of Neurobiology and Anatomy, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Mariajose Perez-HurtadoDepartment of Neurobiology and Anatomy, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Ruth HeidelbergerDepartment of Neurobiology and Anatomy, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

Funding

Mechanisms of Neurotransmisson in Vertebrate RetinaR01EY012128 · NEI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HEIDELBERGER, RUTH · 2003 to 2025
$8.0M
UTHouston Core Center for Vision ResearchP30EY028102 · NEI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MASSEY, STEPHEN C · 2017 to 2021
$3.1M
MECHANISMS OF NEUROTRANSMISSION IN VERTEBRATE RETINAR29EY012128 · NEI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HEIDELBERGER, RUTH · 1998 to 2002
$343k
NEI NIH HHS P30 EY028102NEI NIH HHS R01 EY012128NEI NIH HHS R29 EY012128NIH HHS EY012128-21Vale Asche Foundation Frederic B. Asche Endowment
6 · The paper itself

Abstract

Syntaxin 3 is a member of a large protein family of syntaxin proteins that mediate fusion between vesicles and their target membranes. Mutations in the ubiquitously expressed syntaxin 3A splice form give rise to a serious gastrointestinal disorder in humans called microvillus inclusion disorder, while mutations that additionally involve syntaxin 3B, a splice form that is expressed primarily in retinal photoreceptors and bipolar cells, additionally give rise to an early onset severe retinal dystrophy. In this review, we discuss recent studies elucidating the roles of syntaxin 3B and the regulation of syntaxin 3B functionality in membrane fusion and neurotransmitter release in the vertebrate retina.

Indexed as

Qa-SNARE ProteinsAnimalsHumansMembrane FusionMutationSNARE ProteinsVision, OcularQa-SNARE ProteinsSNARE Proteinsexocytosismembrane fusionretinaretinal degenerationretinal dystrophyribbon synapseSNAREstx3syntaxinsyntaxin 3B

Identifiers

PMID39408994
PMCPMC11476516

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.