Evidence map›Paper›PMID 39408985›Full record

ArticleInternational journal of molecular sciences2024

Paraoxonase-1 as a Cardiovascular Biomarker in Caribbean Hispanic Patients Treated with Clopidogrel: Abundance and Functionality.

Mariangeli Monero-Paredes, Ednalise Santiago, Kelvin Carrasquillo-Carrion, Jessicca Y Renta, Igor B Rogozin, Abiel Roche-Lima, Jorge Duconge

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mariangeli Monero-ParedesDepartment of Pharmacology and Toxicology, School of Medicine, University of Puerto Rico, Medical Sciences Campus, San Juan, PR 00936, USA.
Ednalise SantiagoResearch Centers in Minority Institutions (RCMI) Program, Center for Collaborative Research in Health Disparities (CCRHD), University of Puerto Rico, Medical Sciences Campus, San Juan, PR 00936, USA.
Kelvin Carrasquillo-CarrionResearch Centers in Minority Institutions (RCMI) Program, Center for Collaborative Research in Health Disparities (CCRHD), University of Puerto Rico, Medical Sciences Campus, San Juan, PR 00936, USA.ORCID 0000-0001-7224-2349
Jessicca Y RentaResearch Centers in Minority Institutions (RCMI) Program, Center for Collaborative Research in Health Disparities (CCRHD), University of Puerto Rico, Medical Sciences Campus, San Juan, PR 00936, USA.
Igor B RogozinComputational Biology Branch, National Center for Biotechnology Information (NCBI), National Library of Medicine (NLM), National Institutes of Health (NIH), Rockville Pike MSC 3830, Bethesda, MD 20894, USA.ORCID 0000-0003-0802-4851
Abiel Roche-LimaResearch Centers in Minority Institutions (RCMI) Program, Center for Collaborative Research in Health Disparities (CCRHD), University of Puerto Rico, Medical Sciences Campus, San Juan, PR 00936, USA.ORCID 0000-0003-2246-6744
Jorge DucongeDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico, Medical Sciences Campus, San Juan, PR 00936, USA.ORCID 0000-0002-5955-3449

Funding

Upstream Regulation and Downstream effectors of c-MYC in Ovarian CancerU54MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Emma Fernandez-Repollet · 2017 to 2026
$35.8M
RISE Option III: MBRS RISE at the UPR Medical Sciences CampusR25GM061838 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI CADILLA, CARMEN LYDIA · 2000 to 2021
$25.5M
NIGMS NIH HHS R25 GM061838NIH HHS 1R25GM061838-00S1NIH HHS 2U54MD007600-02S31NIMHD NIH HHS U54 MD007600
6 · The paper itself

Abstract

Clopidogrel, a prescription drug to reduce ischemic events in cardiovascular patients, has been extensively studied in mostly European individuals but not among Caribbean Hispanics. This study evaluated the low abundance and reduced activity of paraoxonase-1 (PON1) in clopidogrel-resistant patients as a predictive risk biomarker of poor responders and disease severity in this population. Thirty-six patients on clopidogrel (cases divided into poor and normal responders) were enrolled, along with 11 cardiovascular patients with no clopidogrel indications (positive control) and 13 healthy volunteers (negative control). Residual on-treatment platelet reactivity unit (PRU), PON1 abundance by Western blotting, and PON1 activity by enzymatic assays were measured.

Indexed as

AryldialkylphosphataseBiomarkersClopidogrelHispanic or LatinoAgedCardiovascular DiseasesCaribbean PeopleFemaleHaplotypesHumansMaleMiddle AgedPlatelet Aggregation InhibitorsPolymorphism, Single NucleotideAryldialkylphosphataseBiomarkersClopidogrelPlatelet Aggregation InhibitorsPON1 protein, humancardiovascular diseasesCaribbean HispanicsclopidogrelPON1resistance

Identifiers

PMID39408985
PMCPMC11477108

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.