Evidence map›Paper›PMID 39408981›Full record

ArticleInternational journal of molecular sciences2024

Effects of Zinc Phthalocyanine Photodynamic Therapy on Vital Structures and Processes in Hela Cells.

Jakub Hosik, Barbora Hosikova, Svatopluk Binder, Rene Lenobel, Marketa Kolarikova, Lukas Malina, Hanna Dilenko, Katerina Langova, Robert Bajgar, Hana Kolarova

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jakub HosikDepartment of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University, 77900 Olomouc, Czech Republic.
Barbora HosikovaDepartment of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University, 77900 Olomouc, Czech Republic.
Svatopluk BinderDepartment of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University, 77900 Olomouc, Czech Republic.
Rene LenobelLaboratory of Growth Regulators, Faculty of Science, Palacky University and Institute of Experimental Botany of the Czech Academy of Sciences, 77900 Olomouc, Czech Republic.
Marketa KolarikovaDepartment of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University, 77900 Olomouc, Czech Republic.ORCID 0000-0002-4745-2667
Lukas MalinaDepartment of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University, 77900 Olomouc, Czech Republic.ORCID 0000-0001-5734-5921
Hanna DilenkoDepartment of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University, 77900 Olomouc, Czech Republic.ORCID 0000-0002-8801-2094
Katerina LangovaDepartment of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University, 77900 Olomouc, Czech Republic.
Robert BajgarDepartment of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University, 77900 Olomouc, Czech Republic.
Hana KolarovaDepartment of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University, 77900 Olomouc, Czech Republic.

Funding

The Ministry of Health Czech Republic NU21J-03-00062
6 · The paper itself

Abstract

This work presents results on the efficiency of newly designed zinc phthalocyanine-mediated photodynamic therapy of both tumoral and nontumoral cell models using the MTT assay. Further detailed examinations of mechanistic and cell biological effects were focused on the HELA cervical cancer cell model. Here, ROS production, changes in the mitochondrial membrane potential, the determination of genotoxicity, and protein changes determined by capillary chromatography and tandem mass spectrometry with ESI were analyzed. The results showed that, in vitro, 5 Jcm

Indexed as

IndolesIsoindolesMembrane Potential, MitochondrialOrganometallic CompoundsPhotochemotherapyPhotosensitizing AgentsReactive Oxygen SpeciesZinc CompoundsDNA DamageHeLa CellsHumansOxidative StressIndolesIsoindolesOrganometallic CompoundsPhotosensitizing AgentsReactive Oxygen SpeciesZinc CompoundsZn(II)-phthalocyanineDNAliposomemitochondriaoxidative stressphotodynamic therapyproteinsreactive oxygen species

Identifiers

PMID39408981
PMCPMC11476877

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.