Evidence map›Paper›PMID 39408962›Full record

ArticleInternational journal of molecular sciences2024

Toxicological Evaluation of Kaempferol and Linearolactone as Treatments for Amoebic Liver Abscess Development in

Luis Varela-Rodríguez, Fernando Calzada, José Antonio Velázquez-Domínguez, Verónica Ivonne Hernández-Ramírez, Hugo Varela-Rodríguez, Elihú Bautista, Mayra Herrera-Martínez, Diana Laura Pichardo-Hernández, Rodrigo Daniel Castellanos-Mijangos, Bibiana Chávez-Munguía and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Luis Varela-RodríguezFacultad de Ciencias Químicas (FCQ), Universidad Autónoma de Chihuahua (UACH), Chihuahua 31125, CP, Mexico.ORCID 0000-0001-8808-8403
Fernando CalzadaUnidad de Investigación Médica en Farmacología, Hospital de Especialidades UMAE-CMNSXXI-IMSS, Ciudad de México 06725, CP, Mexico.ORCID 0000-0003-1851-5988
José Antonio Velázquez-DomínguezDepartamento de Infectómica y Patogénesis Molecular, CINVESTAV-IPN, Ciudad de México 07360, CP, Mexico.ORCID 0000-0003-4504-8166
Verónica Ivonne Hernández-RamírezDepartamento de Infectómica y Patogénesis Molecular, CINVESTAV-IPN, Ciudad de México 07360, CP, Mexico.ORCID 0000-0002-1743-939X
Hugo Varela-RodríguezFacultad de Ciencias Químicas (FCQ), Universidad Autónoma de Chihuahua (UACH), Chihuahua 31125, CP, Mexico.ORCID 0000-0001-5258-9222
Elihú BautistaUnidad de Ciencias Ambientales, IPICYT, San Luis Potosí 78216, CP, Mexico.
Mayra Herrera-MartínezInstituto de Farmacobiología, Universidad de la Cañada (UNCA), Teotitlán de Flores Magón, Oax 68540, CP, Mexico.ORCID 0000-0003-1734-9500
Diana Laura Pichardo-HernándezDepartamento de Infectómica y Patogénesis Molecular, CINVESTAV-IPN, Ciudad de México 07360, CP, Mexico.
Rodrigo Daniel Castellanos-MijangosUnidad de Imagenología Diagnóstica, Centro Médico ISSEMyM-Arturo Montiel Rojas, Metepec 52170, CP, Mexico.
Bibiana Chávez-MunguíaDepartamento de Infectómica y Patogénesis Molecular, CINVESTAV-IPN, Ciudad de México 07360, CP, Mexico.
Patricia Talamás-RohanaDepartamento de Infectómica y Patogénesis Molecular, CINVESTAV-IPN, Ciudad de México 07360, CP, Mexico.ORCID 0000-0002-5085-814X

Funding

ENDORPHINS: TOLERANCE AND DEPENDENCER01DA002013 · NIDA · NEW YORK UNIVERSITY · PI MUSACCHIO, JOSE M · 1986 to 1988
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Consejo Nacional de Humanidades, Ciencias y Tecnologías 103584Consejo Nacional de Humanidades, Ciencias y Tecnologías 371147Consejo Nacional de Humanidades, Ciencias y Tecnologías CB-2013-01-221136
6 · The paper itself

Abstract

Several studies with kaempferol (KP) and linearolactone (LL) have demonstrated their antiparasitic activity. However, the toxicity of these treatments is unknown. Therefore, this study aimed to evaluate the possible toxicological effects of intraperitoneal (i.p.) administration of KP or LL on the amoebic liver abscess model (ALA) in

Indexed as

KaempferolsLiverLiver Abscess, AmebicMesocricetusAnimalsCricetinaeDisease Models, AnimalEntamoeba histolyticaMagnetic Resonance ImagingMalekaempferolKaempferolsamoebic liver abscessEntamoeba histolyticakaempferollinearolactoneMesocricetus auratustoxicity

Identifiers

PMID39408962
PMCPMC11477209

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.