Evidence map›Paper›PMID 39408927›Full record

ArticleInternational journal of molecular sciences2024

YKL40/Integrin β4 Axis Induced by the Interaction between Cancer Cells and Tumor-Associated Macrophages Is Involved in the Progression of High-Grade Serous Ovarian Carcinoma.

Keitaro Yamanaka, Yu-Ichiro Koma, Satoshi Urakami, Ryosuke Takahashi, Satoshi Nagamata, Masaki Omori, Rikuya Torigoe, Hiroki Yokoo, Takashi Nakanishi, Nobuaki Ishihara and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Keitaro YamanakaDivision of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Yu-Ichiro KomaDivision of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.ORCID 0000-0002-3022-8466
Satoshi UrakamiDivision of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Ryosuke TakahashiDivision of Obstetrics and Gynecology, Department of Surgery Related, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Satoshi NagamataDivision of Obstetrics and Gynecology, Department of Surgery Related, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Masaki OmoriDivision of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Rikuya TorigoeDivision of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Hiroki YokooDivision of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Takashi NakanishiDivision of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Nobuaki IshiharaDivision of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Shuichi TsukamotoDivision of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.ORCID 0000-0002-6192-7542
Takayuki KodamaDivision of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.ORCID 0000-0002-6518-5574
Mari NishioDivision of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.ORCID 0000-0002-7413-0751
Manabu ShigeokaDivision of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.ORCID 0000-0003-1130-7166
Hiroshi YokozakiDivision of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.ORCID 0000-0001-5276-3331
Yoshito TeraiDivision of Obstetrics and Gynecology, Department of Surgery Related, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.ORCID 0000-0002-5581-8518

Funding

Japan Society for the Promotion of Science 20K09643Japan Society for the Promotion of Science 22K06978
6 · The paper itself

Abstract

Macrophages in the tumor microenvironment, termed tumor-associated macrophages (TAMs), promote the progression of various cancer types. However, many mechanisms related to tumor-stromal interactions in epithelial ovarian cancer (EOC) progression remain unclear. High-grade serous ovarian carcinoma (HGSOC) is the most malignant EOC subtype. Herein, immunohistochemistry was performed on 65 HGSOC tissue samples, revealing that patients with a higher infiltration of CD68

Indexed as

Cell ProliferationChitinase-3-Like Protein 1Cystadenocarcinoma, SerousDisease ProgressionIntegrin beta4Ovarian NeoplasmsTumor-Associated MacrophagesCarcinoma, Ovarian EpithelialCell Line, TumorCell MovementCoculture TechniquesFemaleHumansMiddle AgedNeoplasm GradingPrognosisCHI3L1 protein, humanChitinase-3-Like Protein 1Integrin beta4ITGB4 protein, humanepithelial ovarian cancerhigh-grade serous ovarian carcinomatumor-associated macrophagestumor microenvironmentYKL40

Identifiers

PMID39408927
PMCPMC11477481

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.