Evidence map›Paper›PMID 39408920›Full record

ArticleInternational journal of molecular sciences2024

Role of Genetic Polymorphisms -238 G>A and -308 G>A, and Serum TNF-α Levels in a Cohort of Mexican Pediatric Neuroblastoma Patients: Preliminary Study.

Arturo Ramírez-Pacheco, Silvia Selene Moreno-Guerrero, Luz María Rocha-Ramírez, Gabriela Hernández-Pliego, María Argelia Escobar-Sánchez, Alfonso Reyes-López, Juan José Luis Sienra-Monge, Luis Enrique Juárez-Villegas

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Association ofInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Article
  4. Associations ofTranslational pediatrics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Arturo Ramírez-PachecoDepartamento de Hemato-Oncología, Hospital Infantil de México Federico Gómez, Dr. Márquez No. 162, Col Doctores, Ciudad de México 06720, Mexico.
Silvia Selene Moreno-GuerreroDepartamento de Hemato-Oncología, Hospital Infantil de México Federico Gómez, Dr. Márquez No. 162, Col Doctores, Ciudad de México 06720, Mexico.
Luz María Rocha-RamírezUnidad de Investigación en Enfermedades Infecciosas, Hospital Infantil de México Federico Gómez, Dr. Márquez No. 162, Col Doctores, Ciudad de México 06720, Mexico.ORCID 0000-0002-7204-1421
Gabriela Hernández-PliegoDepartamento de Hemato-Oncología, Hospital Infantil de México Federico Gómez, Dr. Márquez No. 162, Col Doctores, Ciudad de México 06720, Mexico.
María Argelia Escobar-SánchezDepartamento de Patología Clínica y Experimental, Hospital Infantil de México Federico Gómez, Dr. Márquez No. 162, Col Doctores, Ciudad de México 06720, Mexico.
Alfonso Reyes-LópezCentro de Estudios Económicos y Sociales en Salud, Hospital Infantil de México Federico Gómez, Dr. Márquez No. 162, Col Doctores, Ciudad de México 06720, Mexico.ORCID 0000-0002-6249-3678
Juan José Luis Sienra-MongeSubdirección de Pediatría Ambulatoria, Hospital Infantil de México Federico Gómez, Dr. Márquez No. 162, Col Doctores, Ciudad de México 06720, Mexico.ORCID 0000-0001-5712-052X
Luis Enrique Juárez-VillegasDepartamento de Hemato-Oncología, Hospital Infantil de México Federico Gómez, Dr. Márquez No. 162, Col Doctores, Ciudad de México 06720, Mexico.

Funding

Consejo Nacional de Humanidades, Ciencias y Tecnologías 272420
6 · The paper itself

Abstract

The results of in vitro and in vivo studies have shown the pro-tumor effects of TNF-α, and this cytokine's increased expression is associated with poor prognosis in patients with some types of cancer. Our study objective was to evaluate the possible association of TNF-α genetic polymorphisms and serum levels with susceptibility and prognosis in a cohort of Mexican patients with NB. We performed PCR-RFLP and ELISA methods to analyze the genetics of these SNPs and determine serum concentrations, respectively. The distribution of the -308 G>A and -238 G>A polymorphisms

Indexed as

Genetic Predisposition to DiseaseNeuroblastomaPolymorphism, Single NucleotideTumor Necrosis Factor-alphaCase-Control StudiesChildChild, PreschoolCohort StudiesFemaleGenotypeHumansInfantMaleMexicoPrognosisTumor Necrosis Factor-alphacancer susceptibilityneuroblastomapolymorphismsprognosissurvivalTNF-α

Identifiers

PMID39408920
PMCPMC11477149

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.