Evidence map›Paper›PMID 39408911›Full record

ArticleInternational journal of molecular sciences2024

3-Alkoxy-1-Benzyl-5-Nitroindazole Derivatives Are Potent Antileishmanial Compounds.

Niurka Mollineda-Diogo, Sergio Sifontes-Rodríguez, María Magdalena Aguirre-García, Alma Reyna Escalona-Montaño, Teresa Espinosa-Buitrago, Ricardo Mondragón-Flores, Mónica Edith Mondragón-Castelán, Alfredo Meneses-Marcel, Ofelia Pérez-Olvera, Daniel Andrés Sánchez-Almaraz and 2 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Indazole Derivatives Against Murine Cutaneous Leishmaniasis.Pharmaceuticals (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Niurka Mollineda-DiogoCentro de Bioactivos Químicos, Universidad Central "Marta Abreu" de Las Villas, Santa Clara, Villa Clara 250512, Cuba.ORCID 0000-0001-5137-0253
Sergio Sifontes-RodríguezInstituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México-Consejo Nacional de Humanidades, Ciencias y Tecnologías (CONAHCYT), Ciudad de México 14080, Mexico.ORCID 0000-0003-1226-8648
María Magdalena Aguirre-GarcíaUnidad de Investigación UNAM-INC, Facultad de Medicina, Universidad Nacional Autónoma de México-Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México 14080, Mexico.ORCID 0000-0001-8696-9995
Alma Reyna Escalona-MontañoUnidad de Investigación UNAM-INC, Facultad de Medicina, Universidad Nacional Autónoma de México-Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México 14080, Mexico.ORCID 0000-0002-0060-2939
Teresa Espinosa-BuitragoFacultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660 Madrid, Spain.ORCID 0000-0002-6435-4380
Ricardo Mondragón-FloresDepartamento de Bioquímica, Centro de Investigaciones y Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV), Ciudad de México 14080, Mexico.ORCID 0000-0003-1913-9945
Mónica Edith Mondragón-CastelánDepartamento de Bioquímica, Centro de Investigaciones y Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV), Ciudad de México 14080, Mexico.
Alfredo Meneses-MarcelCentro de Bioactivos Químicos, Universidad Central "Marta Abreu" de Las Villas, Santa Clara, Villa Clara 250512, Cuba.
Ofelia Pérez-OlveraUnidad de Investigación UNAM-INC, Facultad de Medicina, Universidad Nacional Autónoma de México-Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México 14080, Mexico.
Daniel Andrés Sánchez-AlmarazUnidad de Investigación UNAM-INC, Facultad de Medicina, Universidad Nacional Autónoma de México-Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México 14080, Mexico.
Yunierkis Perez-CastilloGrupo de Bio-Quimioinformática and Facultad de Ingeniería y Ciencias Aplicadas, Universidad de Las Américas, Quito 170125, Ecuador.ORCID 0000-0002-3710-0035
Vicente Arán-RedóInstituto de Química Médica del Consejo Superior de Investigaciones Científicas de España, Juan de la Cierva 3, 28006 Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Indazoles have previously been identified as molecules with antiprotozoal activity. In this study, we evaluate the in vitro activity of thirteen 3-alkoxy-1-benzyl-5-nitroindazole derivatives (series D) against

Indexed as

Antiprotozoal AgentsIndazolesMacrophages, PeritonealAnimalsLeishmaniaMiceMice, Inbred BALB C5-nitroindazoleAntiprotozoal AgentsIndazoles2-benzyl-5-nitroindazolin-3-one3-alkoxy-1-benzyl-5-nitroindazoleamastigoteantileishmanial activityleishmaniasispromastigote

Identifiers

PMID39408911
PMCPMC11477194

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.