Evidence map›Paper›PMID 39408897›Full record

ReviewInternational journal of molecular sciences2024

Review of Novel Surgical, Radiation, and Systemic Therapies and Clinical Trials in Glioblastoma.

Allison R Valerius, Lauren M Webb, Anna Thomsen, Eric J Lehrer, William G Breen, Jian L Campian, Cecile Riviere-Cazaux, Terry C Burns, Ugur Sener

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Multimodal PET-MR segmentation for glioblastoma: complementarity for treatment planning and recurrence definition.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
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  13. Functional Biomaterials: Scaffolds for Innovative Treatments.Journal of functional biomaterials · 2025
    Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Allison R ValeriusDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-1708-6205
Lauren M WebbDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-4937-6848
Anna ThomsenDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Eric J LehrerDepartment of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA.
William G BreenDepartment of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Jian L CampianDepartment of Medical Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Cecile Riviere-CazauxDepartment of Neurosurgery, Mayo Clinic, Rochester, MN 55905, USA.
Terry C BurnsDepartment of Neurosurgery, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-7633-3045
Ugur SenerDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-3919-7408

Funding

Mayo Clinic Center for Clinical and Translational Science (CCaTS UL1 Supplement - Dr. Timothy Curry)UL1TR002377 · NCATS · MAYO CLINIC ROCHESTER · PI VESNA D GAROVIC · 2017 to 2026
$78.4M
MSTP at Mayo Clinic RochesterT32GM145408 · NIGMS · MAYO CLINIC ROCHESTER · PI SCOTT H KAUFMANN, LISA A SCHIMMENTI · 2023 to 2026
$4.7M
Glioma intelligence from behind enemy linesR37CA276851 · NCI · MAYO CLINIC ROCHESTER · PI Terry Burns · 2023 to 2026
$2.1M
Intracranial D-2-Hydroxyglutarate as a Monitoring Biomarker for IDH-mutant Glioma.R61NS122096 · NINDS · MAYO CLINIC ROCHESTER · PI BURNS, TERRY · 2022 to 2024
$1.2M
NCATS NIH HHS UL1 TR002377NCI NIH HHS R37 CA276851NIGMS NIH HHS T32 GM145408NINDS NIH HHS R61 NS122096
6 · The paper itself

Abstract

Glioblastoma (GBM) is the most common malignant primary brain tumor in adults. Despite an established standard of care including surgical resection, radiation therapy, and chemotherapy, GBM unfortunately is associated with a dismal prognosis. Therefore, researchers are extensively evaluating avenues to expand GBM therapy and improve outcomes in patients with GBM. In this review, we provide a broad overview of novel GBM therapies that have recently completed or are actively undergoing study in clinical trials. These therapies expand across medical, surgical, and radiation clinical trials. We additionally review methods for improving clinical trial design in GBM.

Indexed as

Brain NeoplasmsClinical Trials as TopicGlioblastomaCombined Modality TherapyHumansglioblastomahigh-grade gliomaimmunotherapyradiation therapyreview of therapysurgical therapytargeted molecular therapy

Identifiers

PMID39408897
PMCPMC11477105

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.