Evidence map›Paper›PMID 39408846›Full record

ArticleInternational journal of molecular sciences2024

27-Hydroxycholesterol Negatively Affects the Function of Bone Marrow Endothelial Cells in the Bone Marrow.

Soo-Yeon Woo, Wan-Seog Shim, Hyejin Lee, Ninib Baryawno, Parkyong Song, Byoung Soo Kim, Sik Yoon, Sae-Ock Oh, Dongjun Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Soo-Yeon WooDepartment of Convergence Medicine, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea.ORCID 0000-0002-2769-3420
Wan-Seog ShimDepartment of Convergence Medicine, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea.
Hyejin LeeDepartment of Convergence Medicine, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea.
Ninib BaryawnoChildhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, 17177 Stockholm, Sweden.
Parkyong SongDepartment of Convergence Medicine, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea.ORCID 0000-0002-5004-3389
Byoung Soo KimSchool of Biomedical Convergence Engineering, Pusan National University, Yangsan 50612, Republic of Korea.ORCID 0000-0002-6693-0003
Sik YoonDepartment of Anatomy, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea.ORCID 0000-0002-6449-0761
Sae-Ock OhDepartment of Anatomy, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea.
Dongjun LeeDepartment of Convergence Medicine, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea.ORCID 0000-0001-6828-401X

Funding

Basic Science Research Program 2022R1A5A2027161Basic Science Research Program RS-2023-00223764Basic Science Research Program RS-2024-00333287Korean Cell-Based Artificial Blood Project RS-2023-KH140743
6 · The paper itself

Abstract

Hematopoietic stem cells (HSCs) reside in specific microenvironments that facilitate their regulation through both internal mechanisms and external cues. Bone marrow endothelial cells (BMECs), which are found in one of these microenvironments, play a vital role in controlling the self-renewal and differentiation of HSCs during hematological stress. We previously showed that 27-hydroxycholesterol (27HC) administration of exogenous 27HC negatively affected the population of HSCs and progenitor cells by increasing the reactive oxygen species levels in the bone marrow. However, the effect of 27HC on BMECs is unclear. To determine the function of 27HC in BMECs, we employed magnetic-activated cell sorting to isolate CD31

Indexed as

Bone Marrow CellsEndothelial CellsHematopoietic Stem CellsHydroxycholesterolsAnimalsBone MarrowCell DifferentiationCells, CulturedMiceMice, Inbred C57BLPlatelet Endothelial Cell Adhesion Molecule-1Reactive Oxygen Species27-hydroxycholesterolHydroxycholesterolsPlatelet Endothelial Cell Adhesion Molecule-1Reactive Oxygen Species27-hydroxycholesterolbone marrow endothelial cellhematopoietic stem cell

Identifiers

PMID39408846
PMCPMC11477443

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.